The effect of silver diamine fluoride in preventing in vitro primary coronal caries under pH-cycling conditions

• Published in: Archives of oral biology Vol. 121; p. 104950
• Main Authors: Sorkhdini, Parand, Crystal, Yasmi O., Tang, Qing, Lippert, Frank
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2021
• Subjects: Caries prevention; Cariostatic Agents - pharmacology; Dark staining; Demineralization; Dental Caries - prevention & control; Dentistry; Fluoride; Fluorides, Topical - pharmacology; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; pH-cycling; Quaternary Ammonium Compounds - pharmacology; Silver Compounds - pharmacology; Silver diamine fluoride; Sodium Fluoride - pharmacology; pH-cycling; Demineralization; Fluoride; Silver diamine fluoride; Caries prevention; Dark staining
• ISSN: 0003-9969; 1879-1506
• DOI: 10.1016/j.archoralbio.2020.104950

•This study assessed the ability of Silver diamine fluoride to prevent enamel caries.•pH-cycling conditions with and without fluoride were utilized.•Silver diamine fluoride appears to be effective in the prevention of enamel caries.•Potassium iodide helped prevent dark staining caused by Silver diamine fluoride.•Potassium iodide did not impair anti- caries ability of Silver diamine fluoride. This study investigated the ability of SDF, and its individual components, silver (Ag+) and fluoride (F−) ions, in preventing enamel demineralization under pH-cycling conditions in the presence or absence of twice-daily fluoride application. Polished human enamel specimens were assigned to five treatment groups (n = 36 per group): SDF (38 %); SDF followed by application of a saturated solution of potassium iodide (SDF + KI); silver nitrate (AgNO3; silver control, 253,900 ppm Ag); potassium fluoride (KF; fluoride control, 44,800 ppm F); deionized water. Treatments were applied once. Specimens in each treatment group were divided into two subgroups (n = 18). During the subsequent 7-day pH-cycling phase, specimens were treated twice daily with either 275 ppm fluoride as sodium fluoride or deionized water, immediately before and after a 3-h cariogenic challenge with exposure to artificial saliva at all other times. Changes in color, Vickers surface microhardness (SMH), transverse microradiography (TMR) was calculated. Data were analyzed using two-way ANOVA. In both models, SDF, SDF + KI and KF were superior in inhibiting demineralization compared to AgNO3 and deionized water (p < 0.0001). There was no statistically significant difference between SDF, SDF + KI and KF with twice daily fluoride treatments (p > 0.8). However, KF was more effective in preventing demineralization than SDF and SDF + KI in the absence of fluoride treatments (p = 0.0002). KI did not affect the ability of SDF to prevent demineralization (p > 0.4). SDF and SDF + KI appears to be an effective option in preventing primary coronal caries.