Low-Dose Difluoromethylornithine and Polyamine Levels in Human Prostate Tissue

• Published in: JNCI : Journal of the National Cancer Institute Vol. 91; no. 16; pp. 1416 - 1417
• Main Authors: Messing, Edward M., Love, Richard R., Tutsch, Kendra D., Verma, Ajit K., Douglas, Jeffrey, Pomplun, Marcia, Simsiman, Ruby, Wilding, George
• Format: Journal Article
• Language: English
• Published: Cary, NC Oxford University Press 18.08.1999; Oxford Publishing Limited (England)
• Subjects: Administration, Oral; Antineoplastic agents; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - pharmacology; Biological and medical sciences; Cells; Chemotherapy; Eflornithine - administration & dosage; Eflornithine - pharmacology; Enzyme Inhibitors - administration & dosage; Enzyme Inhibitors - pharmacology; Humans; Male; Medical research; Medical sciences; Ornithine Decarboxylase Inhibitors; Pharmacology. Drug treatments; Polyamines - analysis; Prostate - chemistry; Prostate - drug effects; Prostate - enzymology; Prostate - surgery; Prostate cancer; Prostatic Neoplasms - chemistry; Prostatic Neoplasms - enzymology; Prostatic Neoplasms - surgery; Putrescine - analysis; Tissues; Urinary Bladder Neoplasms - chemistry; Urinary Bladder Neoplasms - enzymology; Urinary Bladder Neoplasms - surgery; Antineoplastic agent; Human; Polyamine; Urinary system disease; Prostate disease; Enzyme; Low dose; Enzyme inhibitor; Lyases; Ornithine decarboxylase; Malignant tumor; Carbon-carbon lyases; Chemotherapy; Treatment; Carboxy-lyases; Male genital diseases; Prostate
• ISSN: 0027-8874; 1460-2105
• DOI: 10.1093/jnci/91.16.1416

Difluoromethylornithine is a non-competitive inhibitor of ornithine decarboxylase, which catalyzes the rate-limiting step in polyamine synthesis. Futher studies of difluoromethylornithine in populations at risk for prostate cancer seem to be warranted.