Anti-allergic effects of vitamin E in allergic diseases: An updated review

•Consumption of vitamin E (Vit E) may reduce inflammation which improve allergy symptoms.•The Inhibition of cell proliferation could be induced by Vit E through Protein phosphatase 2 (PP2A).•Vit E inhibits Eosinophilic and Neutrophilic inflammation via STAT6 inhibition.•The production of inflammator...

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Published inInternational immunopharmacology Vol. 90; p. 107196
Main Authors Shams, Mohammad-Hossein, Jafari, Reza, Eskandari, Nahid, Masjedi, Mohsen, Kheirandish, Farnaz, Ganjalikhani Hakemi, Mazdak, Ghasemi, Ramin, Varzi, Ali-Mohammad, Sohrabi, Seyyed-Mohsen, Baharvand, Peyman Amanolahi, Safari, Mozhgan
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.01.2021
Subjects
Allergic rhinitis
Antioxidant
Asthma
Atopic dermatitis
Food allergy
Vitamin E
Food allergy
Antioxidant
Vitamin E
Atopic dermatitis
Allergic rhinitis
Asthma
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Summary:•Consumption of vitamin E (Vit E) may reduce inflammation which improve allergy symptoms.•The Inhibition of cell proliferation could be induced by Vit E through Protein phosphatase 2 (PP2A).•Vit E inhibits Eosinophilic and Neutrophilic inflammation via STAT6 inhibition.•The production of inflammatory cytokines, and ROS as well as the Th2 response are inhibited by Vit E. Allergic diseases are caused by the immune system's response to innocent antigens called allergens. Recent decades have seen a significant increase in the prevalence of allergic diseases worldwide, which has imposed various socio-economic effects in different countries. Various factors, including genetic factors, industrialization, improved hygiene, and climate change contribute to the development of allergic diseases in many parts of the world. Moreover, changes in lifestyle and diet habits play pivotal roles in the prevalence of allergic diseases. Dietary changes caused by decreased intake of antioxidants such as vitamin E lead to the generation of oxidative stress, which is central to the development of allergic diseases. It has been reported in many articles that oxidative stress diverts immune responses to the cells associated with the pathogenesis of allergic diseases. The aim of this short review was to summarize current knowledge about the anti-allergic properties of vitamin E.
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2020.107196