The Growth Hormone Receptor Gene is Associated with Mandibular Height in a Chinese Population

Genetic influences are important in the determination of mandibular morphology, and growth hormone receptor (GHR) is believed to have an important influence on the growth of craniofacial bone. In this study, we used quantitative trait locus methods to evaluate the relationship between craniofacial m...

Full description

Saved in:
Bibliographic Details
Published inJournal of dental research Vol. 84; no. 11; pp. 1052 - 1056
Main Authors Zhou, J., Lu, Y., Gao, X.H., Chen, Y.C., Lu, J.J., Bai, Y.X., Shen, Y., Wang, B.K.
Format Journal Article
LanguageEnglish
Published United States SAGE Publications 01.11.2005
SAGE PUBLICATIONS, INC
Subjects
Adenine
Adult
Cephalometry
Chin - anatomy & histology
China
Cytosine
Dentistry
Exons - genetics
Female
Genotype
Haplotypes
Humans
Introns - genetics
Linkage Disequilibrium - genetics
Male
Mandible - anatomy & histology
Mandible - growth & development
Mandibular Condyle - anatomy & histology
Polymorphism, Genetic - genetics
Polymorphism, Single Nucleotide - genetics
Quantitative Trait Loci - genetics
Receptors, Somatotropin - genetics
China
QTL analysis
mandibular height
single-nucleotide polymorphism
growth hormone receptor gene
Online AccessGet full text

Cover

More Information
Summary:Genetic influences are important in the determination of mandibular morphology, and growth hormone receptor (GHR) is believed to have an important influence on the growth of craniofacial bone. In this study, we used quantitative trait locus methods to evaluate the relationship between craniofacial morphology and single-nucleotide polymorphisms (SNPs) in GHR in an unselected healthy Chinese population. We systematically screened the 10 exons and nearby introns of GHR and identified 6 SNPs. Using 4 SNPs as markers, we studied the relationships between genotypes and craniofacial linear measurements. Individuals with the genotype CC of polymorphism I526L had a significantly greater mandibular ramus length (condylion-gonion/ articulare-gonion) than those with genotype AC or AA. Haplotype analysis showed that there were also significant differences between the long and short mandibular height groups in an extreme population. Our results indicate that the GHR gene polymorphism I526L is associated with mandibular height in the Chinese population.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-0345
1544-0591
DOI:10.1177/154405910508401116