The application of a thiohydroxamic acid (THA) linker in the solid-phase synthesis of a urea library

A library of mono- and bis-ureas were synthesised on resin derivatised with a thiohydroxamic acid (THA) linker. The ureas were obtained in good yields and the resin was recycled three times with no apparent loss of function.

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Bibliographic Details
Published inReactive & functional polymers Vol. 52; no. 2; pp. 81 - 87
Main Authors Whitehead, David M, Jackson, Toby, McKeown, Stephen C, Routledge, Anne
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 01.08.2002
Elsevier Science
Subjects
Applied sciences
Chemistry
Exact sciences and technology
Organic chemistry
Organic polymers
Physicochemistry of polymers
Properties and characterization
Recycle
Solid-support
Special properties (catalyst, reagent or carrier)
Thiohydroxamic acid
Urea
Urea
Thiohydroxamic acid
Solid-support
Recycle
Thiocarbohydroxamic acid
Combinatorial chemistry
Experimental study
Styrene derivative polymer
Chemical modification
Aminolysis
Preparation
Chemical compound library
Crosslinked polymer
Cleavage
Sulfur containing polymer
Ureas
Reaction support
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Summary:A library of mono- and bis-ureas were synthesised on resin derivatised with a thiohydroxamic acid (THA) linker. The ureas were obtained in good yields and the resin was recycled three times with no apparent loss of function.
ISSN:1381-5148
DOI:10.1016/S1381-5148(02)00082-2