Sleep-wake dynamics pre- and post-exposure to chronic social stress

• Published in: iScience Vol. 24; no. 10; p. 103204
• Main Authors: Radwan, Basma, Jansen, Gloria, Chaudhury, Dipesh
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 22.10.2021; Elsevier
• Subjects: behavioral neuroscience; systems neuroscience; behavioral neuroscience; systems neuroscience
• ISSN: 2589-0042; 2589-0042
• DOI: 10.1016/j.isci.2021.103204

An analytical approach combining the statistical distributions of the sleep-wake bouts and the Markov transition matrix is used to explain the under-examined association between the microarchitecture of the sleep-wake cycle and susceptibility to chronic social stress in C57BL/6J mice. We separated the sleep-wake transitions into distinct sleep-wake sequences, NREM↔Wake and NREM→REM→Wake, which are controlled by independent neural circuits. Our findings imply greater pull toward the wake leading to early termination and fragmentation of the sleep bouts in the light in both sleep-wake sequences pre- and post-stress. Moreover, the stability of NREM in the NREM↔Wake transition was lower, and the probability of transitioning to wake was higher in susceptible relative to resilient or stress-naïve mice pre- and post-stress. Our findings help elucidate the mechanistic interplay between sleep and mood by suggesting the potential neural underpinnings of sleep disturbances responsible the aberrant transitions of sleep-wake bouts exhibited by the stress-susceptible phenotype. [Display omitted] •Transition between sleep and wake are segregated into a short and long sleep states•NREM stability during short sleep is lower in susceptible mice pre- and post-stress•More NREM and wake bouts during short sleep in susceptible mice pre- and post-stress•Increased fragmented sleep in susceptible mice pre- and post-stress Behavioral neuroscience; Systems neuroscience