Mapping of c-Fos expression in male tree shrew forebrain

• Published in: Neuroscience letters Vol. 714; p. 134603
• Main Authors: Ni, Rong-Jun, Wang, Jing, Shu, Yu-Mian, Xu, Lin, Zhou, Jiang-Ning
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.01.2020
• Subjects: Amygdala; Animals; Arcuate Nucleus of Hypothalamus - metabolism; Aversive stimulus; Bed nucleus of the stria terminalis; Corticomedial Nuclear Complex - metabolism; Electroshock; Hypothalamic Area, Lateral - metabolism; Hypothalamus; Lateral septal nucleus; Male; Paraventricular Hypothalamic Nucleus - metabolism; Prefrontal cortex; Prefrontal Cortex - metabolism; Prosencephalon - metabolism; Proto-Oncogene Proteins c-fos - metabolism; Restraint, Physical; Septal Nuclei - metabolism; Supraoptic Nucleus - metabolism; Tupaiidae - metabolism; Ventromedial Hypothalamic Nucleus - metabolism; Aversive stimulus; Lateral septal nucleus; Prefrontal cortex; Hypothalamus; Amygdala; Bed nucleus of the stria terminalis
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/j.neulet.2019.134603

•Mapping of c-Fos expression in the forebrain of the tree shrew.•Patterns of c-Fos expression in tree shrew forebrain following aversive stimuli.•Distinct expression of c-Fos between restraint- and footshock-treated tree shrews.•Aversive valence maps in the tree shrew forebrain by c-Fos immunohistochemistry. The tree shrew is susceptible to stimuli. However, mapping of c-Fos expression in male tree shrew forebrain has not been explored. The present results provided the first detailed mapping of c-Fos expression in the forebrain of the tree shrew (Tupaia belangeri chinensis). Acute restraint stress rapidly increased the density of c-Fos-immunoreactive (-ir) neurons in the medial orbital cortex (MO), infralimbic cortex, intermediate part of the lateral septal nucleus (LSi), ventral part of the lateral septal nucleus (LSv), anterior part of the bed nucleus of the stria terminalis, posterior part of the bed nucleus of the stria terminalis (STP), paraventricular nucleus of the hypothalamus, supraoptic nucleus, lateral hypothalamic area, ventromedial hypothalamic nucleus (VMH), and medial amygdaloid nucleus (MeA). Furthermore, a significant increase in c-Fos expression was observed in the MO, LSi, LSv, STP, VMH, arcuate hypothalamic nucleus, anterior amygdaloid area, MeA, and cortical amygdaloid nucleus immediately after acute footshock stress. In addition, the distinct patterns of c-Fos expression in the forebrain were shown in context-, restraint-, or footshock-treated tree shrews. In general, the present study provides the first detailed maps of c-Fos expression in male tree shrew forebrain immediately after various stimuli.