Cardiaprotective effect of crocetin by attenuating apoptosis in isoproterenol induced myocardial infarction rat model

• Published in: Biomedicine & pharmacotherapy Vol. 93; pp. 376 - 382
• Main Authors: Zhang, Weili, Li, Yuhui, Ge, Zhiming
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.09.2017
• Subjects: Animals; Antioxidant; Apoptosis; Apoptosis - drug effects; bcl-2-Associated X Protein - metabolism; Biomarkers - metabolism; Cardiotonic Agents - pharmacology; Cardiotonic Agents - therapeutic use; Carotenoids - pharmacology; Carotenoids - therapeutic use; Caspase 3 - metabolism; Crocetin; Cytokines; Cytokines - metabolism; Disease Models, Animal; Hemodynamics - drug effects; Inflammation Mediators - metabolism; Isoproterenol; Male; Myocardial infarction; Myocardial Infarction - drug therapy; Myocardial Infarction - pathology; Myocardial Infarction - physiopathology; Myocardium - enzymology; Myocardium - metabolism; Myocardium - pathology; NF-E2-Related Factor 2 - metabolism; Oxidative Stress - drug effects; Rats, Wistar; Ventricular Function, Left - drug effects; Vitamin A - analogs & derivatives; Myocardial infarction; Cytokines; Isoproterenol; Antioxidant; Crocetin; Apoptosis

Given study evaluates the cardioprotective effect of crocetin in myocardial infracted (MI) rats. MI was produced by administering isoproterenol (90mg/kg/day, i.p.) in rats for two consecutive days. all the animals were divided in to four groups such as control group receives only saline; MI group wh...