Copper-catalyzed functionalization of enynes

The copper-catalyzed functionalization of enyne derivatives has recently emerged as a powerful approach in contemporary synthesis. Enynes are versatile and readily accessible substrates that can undergo a variety of reactions to yield densely functionalized, enantioenriched products. In this perspec...

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Published inChemical science (Cambridge) Vol. 11; no. 42; pp. 1138 - 11393
Main Authors Dherbassy, Quentin, Manna, Srimanta, Talbot, Fabien J. T, Prasitwatcharakorn, Watcharapon, Perry, Gregory J. P, Procter, David J
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 07.10.2020
The Royal Society of Chemistry
Subjects
Chemistry
Copper
Substrates
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Summary:The copper-catalyzed functionalization of enyne derivatives has recently emerged as a powerful approach in contemporary synthesis. Enynes are versatile and readily accessible substrates that can undergo a variety of reactions to yield densely functionalized, enantioenriched products. In this perspective, we review copper-catalyzed transformations of enynes, such as boro- and hydrofunctionalizations, copper-mediated radical difunctionalizations, and cyclizations. Particular attention is given to the regiodivergent functionalization of 1,3-enynes, and the current mechanistic understanding of such processes. The copper-catalyzed functionalization of enynes is a powerful approach to yield densely functionalized products. This review covers various transformations, such as boro- and hydrofunctionalizations, copper-mediated radical difunctionalizations, and cyclizations.
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These authors contributed equally to this work.
ISSN:2041-6520
2041-6539
DOI:10.1039/d0sc04012f