Emergence of inflammatory bowel disease ‘beyond the West’: do prosperity and improved hygiene have a role?

Inflammatory bowel disease (IBD) is increasing in many countries ‘beyond the West’. This increase may be due to an increased rate of diagnosis but might also represent a true increase in incidence. Economic development, leading to improved hygiene and other changes in lifestyle, may play a role in t...

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Bibliographic Details
Published inTransactions of the Royal Society of Tropical Medicine and Hygiene Vol. 102; no. 9; pp. 857 - 860
Main Authors de Silva, H.J., de Silva, N.R., de Silva, A.P., Jewell, D.P.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.09.2008
Royal Society of Tropical Medicine and Hygiene
Elsevier
Subjects
Biological and medical sciences
Developing countries
Economic development
Epidemiology. Vaccinations
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Helminth infection
Humans
Hygiene
Incidence
Infectious diseases
Inflammatory bowel disease
Inflammatory Bowel Diseases - economics
Inflammatory Bowel Diseases - epidemiology
Inflammatory Bowel Diseases - etiology
Medical sciences
Other diseases. Semiology
Prevalence
Socioeconomic Factors
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Inflammatory bowel disease
Developing countries
Economic development
Hygiene
Helminth infection
Incidence
West
Parasitosis
Helminthiasis
Inflammatory disease
Infection
Crohn disease
Emergence
Digestive diseases
Intestinal disease
Tropical medicine
Public health
Ulcerative colitis
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Summary:Inflammatory bowel disease (IBD) is increasing in many countries ‘beyond the West’. This increase may be due to an increased rate of diagnosis but might also represent a true increase in incidence. Economic development, leading to improved hygiene and other changes in lifestyle, may play a role in the increase in IBD. However, the marked difference in prevalence between ethnic groups suggests that the genetic background of populations may also be relevant and supports the current hypothesis that IBD represents an interaction between environmental factors and a genetically susceptible host. Investigating the early stages of IBD as it emerges in new populations may provide new clues to its pathophysiology.
Bibliography:ark:/67375/HXZ-XXDBB718-H
istex:6B51139EB08B9C32E7796ABD3BE3FBE85E0D9ABA
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0035-9203
1878-3503
DOI:10.1016/j.trstmh.2008.03.016