The prospects of automation in drug discovery research using silkworms

We have established several models of infectious diseases in silkworms to explore disease-causing mechanisms and identify new antimicrobial substances. These models involve injecting laboratory-cultured pathogens into silkworms and monitoring their survival over a period of days. The use of silkworm...

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Bibliographic Details
Published inDrug Discoveries & Therapeutics Vol. 18; no. 2; pp. 130 - 133
Main Authors Miyauchi, Masanobu, Miyashita, Atsushi, Tabuchi, Fumiaki
Format Journal Article
LanguageEnglish
Published Japan International Research and Cooperation Association for Bio & Socio-Sciences Advancement 30.04.2024
Subjects
alternative animals
Animals
Automation, Laboratory
Bombyx
Disease Models, Animal
Drug Discovery - methods
experimental infection
Humans
laboratory automation
silkworm
alternative animals
experimental infection
laboratory automation
silkworm
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ISSN1881-7831
1881-784X
DOI10.5582/ddt.2024.01013

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Summary:We have established several models of infectious diseases in silkworms to explore disease-causing mechanisms and identify new antimicrobial substances. These models involve injecting laboratory-cultured pathogens into silkworms and monitoring their survival over a period of days. The use of silkworms is advantageous because they are cost-effective and raise fewer ethical concerns than mammalian subjects, allowing for larger experimental group sizes. To capitalize on these benefits, there is a growing importance in mechanizing and automating the experimental processes that currently require manual labor. This paper discusses the future of laboratory automation, specifically through the mechanization and automation of silkworm-based experimental procedures.
ISSN:1881-7831
1881-784X
DOI:10.5582/ddt.2024.01013