Two pediatric osteosarcoma cases with delayed methotrexate excretion: its clinical course and management

High-dose methotrexate (MTX) chemotherapy extends the duration of hospitalization and introduces the risks of serious complications related to delayed MTX excretion. The treatment of delayed MTX excretion is largely dependent on invasive measures such as hemodialysis because the clinical data regard...

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Published inCancer research and treatment Vol. 43; no. 1; pp. 67 - 70
Main Authors Lee, Kang Min, Lee, Hee Woo, Kim, Seung Yeon, Lee, Hyeon Jeong, Kim, Dong Hwan, Cho, Joongbum, Kim, Dong Ho, Lim, Jung Sub, Lee, Jin Kyung, Lee, Jun Ah
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Cancer Association 01.03.2011
대한암학회
Subjects
Case Report
의약학
Complication
Management
Methotrexate
Osteosarcoma
Child
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Summary:High-dose methotrexate (MTX) chemotherapy extends the duration of hospitalization and introduces the risks of serious complications related to delayed MTX excretion. The treatment of delayed MTX excretion is largely dependent on invasive measures such as hemodialysis because the clinical data regarding the efficacy or safety of carboxypetidase G(2) is limited. We report here on the cases of two pediatric osteosarcoma patients with delayed MTX excretion and who were successfully managed using supportive measures. Potential life-threatening complications were prevented by administering high doses of leucovorin.
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http://kmbase.medric.or.kr/Main.aspx?d=KMBASE&m=VIEW&i=0939920110430010067
G704-000841.2011.43.1.007
ISSN:1598-2998
2005-9256
DOI:10.4143/crt.2011.43.1.67