Use of nonobese diabetic mice to understand human type 1 diabetes

In 1922, Leonard Thompson received the first injections of insulin prepared from the pancreas of canine test subjects. From pancreatectomized dogs to the more recent development of animal models that spontaneously develop autoimmune syndromes, animal models have played a meaningful role in furtherin...

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Bibliographic Details
Published inEndocrinology and metabolism clinics of North America Vol. 39; no. 3; p. 541
Main Authors Thayer, Terri C, Wilson, S Brian, Mathews, Clayton E
Format Journal Article
LanguageEnglish
Published United States 01.09.2010
Subjects
Animals
Comprehension
Diabetes Mellitus, Type 1 - etiology
Diabetes Mellitus, Type 1 - genetics
Diabetes Mellitus, Type 1 - immunology
Diabetes Mellitus, Type 1 - therapy
Dogs
Evaluation Studies as Topic
Humans
Mice
Mice, Inbred NOD - genetics
Mice, Inbred NOD - immunology
Mice, Inbred NOD - physiology
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Summary:In 1922, Leonard Thompson received the first injections of insulin prepared from the pancreas of canine test subjects. From pancreatectomized dogs to the more recent development of animal models that spontaneously develop autoimmune syndromes, animal models have played a meaningful role in furthering diabetes research. Of these animals, the nonobese diabetic (NOD) mouse is the most widely used for research in type 1 diabetes (T1D) because the NOD shares several genetic and immunologic traits with the human form of the disease. In this article, the authors discuss the similarities and differences in NOD and human T1D and the potential role of NOD mice in future preclinical studies, aiming to provide a better understanding of the genetic and immune defects that lead to T1D.
ISSN:1558-4410
DOI:10.1016/j.ecl.2010.05.001