Inhibitory Effect of Helicteres gardneriana Ethanol Extract on Acute Inflammation

The anti-inflammatory effect of an ethanol extract of Helicteres gardneriana (Nees) Castiglioni was assayed in experimental models of pleurisy and microcirculation in situ. Treatment of animals with 500 mg/kg body weight reduced the exudate volume (35% reduction) induced by intrapleural injection of...

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Published inEvidence-based complementary and alternative medicine Vol. 2012; no. 2012; pp. 1 - 5
Main Authors Bersani-Amado, Ciomar Aparecida, Caparroz-Assef, Silvana Martins, Truiti, Maria da Conceição Torrado, Baroni, Silmara, de Arruda, Laura Lícia Milani, de Melo, Juliana Oliveira, Cuman, Roberto Kenji Nakamura
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2012
Hindawi Limited
Subjects
Body weight
Carrageenan
Diabetes
Edema
Endothelium
Ethanol
Exudation
Granulocytes
Helicteres
Inflammation
Injection
Leukocyte migration
Leukocytes (polymorphonuclear)
Neutrophils
Permeability
Physiology
Pleural cavity
Pleurisy
Rodents
Vinegar
Weight reduction
Brazil
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Abstract The anti-inflammatory effect of an ethanol extract of Helicteres gardneriana (Nees) Castiglioni was assayed in experimental models of pleurisy and microcirculation in situ. Treatment of animals with 500 mg/kg body weight reduced the exudate volume (35% reduction) induced by intrapleural injection of carrageenan and the migration of polymorphonuclear cells into the inflamed pleural cavity of rats (40%). Additionally, rolling and adhesion of leukocytes and the number of leukocytes that migrated toward the perivascular space in response to the carrageenan injection were decreased by the extract (500 mg/kg). These data demonstrate the anti-inflammatory effect of the ethanol extract of Helicteres gardneriana and imply that inhibition of leukocyte-endothelial interactions is important in the extract's mechanism of action.
AbstractList The anti-inflammatory effect of an ethanol extract of Helicteres gardneriana (Nees) Castiglioni was assayed in experimental models of pleurisy and microcirculation in situ. Treatment of animals with 500 mg/kg body weight reduced the exudate volume (35% reduction) induced by intrapleural injection of carrageenan and the migration of polymorphonuclear cells into the inflamed pleural cavity of rats (40%). Additionally, rolling and adhesion of leukocytes and the number of leukocytes that migrated toward the perivascular space in response to the carrageenan injection were decreased by the extract (500 mg/kg). These data demonstrate the anti-inflammatory effect of the ethanol extract of Helicteres gardneriana and imply that inhibition of leukocyte-endothelial interactions is important in the extract's mechanism of action.
The anti-inflammatory effect of an ethanol extract of Helicteres gardneriana (Nees) Castiglioni was assayed in experimental models of pleurisy and microcirculation in situ . Treatment of animals with 500 mg/kg body weight reduced the exudate volume (35% reduction) induced by intrapleural injection of carrageenan and the migration of polymorphonuclear cells into the inflamed pleural cavity of rats (40%). Additionally, rolling and adhesion of leukocytes and the number of leukocytes that migrated toward the perivascular space in response to the carrageenan injection were decreased by the extract (500 mg/kg). These data demonstrate the anti-inflammatory effect of the ethanol extract of Helicteres gardneriana and imply that inhibition of leukocyte-endothelial interactions is important in the extract's mechanism of action.
Author Bersani-Amado, Ciomar Aparecida
Baroni, Silmara
Caparroz-Assef, Silvana Martins
Truiti, Maria da Conceição Torrado
de Melo, Juliana Oliveira
Cuman, Roberto Kenji Nakamura
de Arruda, Laura Lícia Milani
AuthorAffiliation 1 Laboratory of Inflammation, Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, PR, Brazil
2 Laboratory of Pharmaceutical Technology, Department of Pharmacy, State University of Maringá, Maringá, PR, Brazil
AuthorAffiliation_xml – name: 1 Laboratory of Inflammation, Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, PR, Brazil
– name: 2 Laboratory of Pharmaceutical Technology, Department of Pharmacy, State University of Maringá, Maringá, PR, Brazil
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  fullname: Bersani-Amado, Ciomar Aparecida
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  fullname: Caparroz-Assef, Silvana Martins
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/22028731$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_1007_s11418_014_0839_7
crossref_primary_10_1016_j_jep_2015_03_021
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ContentType Journal Article
Copyright Copyright © 2012 Juliana Oliveira de Melo et al.
Copyright © 2012 Juliana Oliveira de Melo et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0
Copyright © 2012 Juliana Oliveira de Melo et al. 2012
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– notice: Copyright © 2012 Juliana Oliveira de Melo et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0
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Snippet The anti-inflammatory effect of an ethanol extract of Helicteres gardneriana (Nees) Castiglioni was assayed in experimental models of pleurisy and...
The anti-inflammatory effect of an ethanol extract of Helicteres gardneriana (Nees) Castiglioni was assayed in experimental models of pleurisy and...
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SubjectTerms Body weight
Carrageenan
Diabetes
Edema
Endothelium
Ethanol
Exudation
Granulocytes
Helicteres
Inflammation
Injection
Leukocyte migration
Leukocytes (polymorphonuclear)
Neutrophils
Permeability
Physiology
Pleural cavity
Pleurisy
Rodents
Vinegar
Weight reduction
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Title Inhibitory Effect of Helicteres gardneriana Ethanol Extract on Acute Inflammation
URI https://search.emarefa.net/detail/BIM-992034
https://dx.doi.org/10.1155/2012/141947
https://www.ncbi.nlm.nih.gov/pubmed/22028731
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Volume 2012
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