Inhibitory Effect of Helicteres gardneriana Ethanol Extract on Acute Inflammation

• Published in: Evidence-based complementary and alternative medicine Vol. 2012; no. 2012; pp. 1 - 5
• Main Authors: Bersani-Amado, Ciomar Aparecida, Caparroz-Assef, Silvana Martins, Truiti, Maria da Conceição Torrado, Baroni, Silmara, de Arruda, Laura Lícia Milani, de Melo, Juliana Oliveira, Cuman, Roberto Kenji Nakamura
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2012; Hindawi Limited
• Subjects: Body weight; Carrageenan; Diabetes; Edema; Endothelium; Ethanol; Exudation; Granulocytes; Helicteres; Inflammation; Injection; Leukocyte migration; Leukocytes (polymorphonuclear); Neutrophils; Permeability; Physiology; Pleural cavity; Pleurisy; Rodents; Vinegar; Weight reduction; Brazil
• ISSN: 1741-427X; 1741-4288
• DOI: 10.1155/2012/141947

The anti-inflammatory effect of an ethanol extract of Helicteres gardneriana (Nees) Castiglioni was assayed in experimental models of pleurisy and microcirculation in situ. Treatment of animals with 500 mg/kg body weight reduced the exudate volume (35% reduction) induced by intrapleural injection of carrageenan and the migration of polymorphonuclear cells into the inflamed pleural cavity of rats (40%). Additionally, rolling and adhesion of leukocytes and the number of leukocytes that migrated toward the perivascular space in response to the carrageenan injection were decreased by the extract (500 mg/kg). These data demonstrate the anti-inflammatory effect of the ethanol extract of Helicteres gardneriana and imply that inhibition of leukocyte-endothelial interactions is important in the extract's mechanism of action.