Roles of vimentin in health and disease

• Published in: Genes & development Vol. 36; no. 7-8; pp. 391 - 407
• Main Authors: Ridge, Karen M., Eriksson, John E., Pekny, Milos, Goldman, Robert D.
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.04.2022
• Subjects: Animals; Cell and Molecular Biology; Cell Biology; Cell Physiological Phenomena; Cell- och molekylärbiologi; Developmental Biology; fibrillary acidic protein; Genetics & Heredity; hormone-sensitive lipase; intermediate filaments; Intermediate Filaments - genetics; Intermediate Filaments - metabolism; Medical Genetics and Genomics; Medicinsk genetik och genomik; Mice; mice lacking; muller cells; oxidative stress; poor-prognosis; pulmonary-fibrosis; reactive astrocytes; retinal-detachment; Review; vimentin; Vimentin - genetics; Vimentin - metabolism; vimentin-null mouse; vimentin; intermediate filaments; vimentin-null mouse
• ISSN: 0890-9369; 1549-5477; 1549-5477
• DOI: 10.1101/gad.349358.122

More than 27 yr ago, the vimentin knockout ( Vim −/− ) mouse was reported to develop and reproduce without an obvious phenotype, implying that this major cytoskeletal protein was nonessential. Subsequently, comprehensive and careful analyses have revealed numerous phenotypes in Vim −/− mice and their organs, tissues, and cells, frequently reflecting altered responses in the recovery of tissues following various insults or injuries. These findings have been supported by cell-based experiments demonstrating that vimentin intermediate filaments (IFs) play a critical role in regulating cell mechanics and are required to coordinate mechanosensing, transduction, signaling pathways, motility, and inflammatory responses. This review highlights the essential functions of vimentin IFs revealed from studies of Vim −/− mice and cells derived from them.