Exosomes: From Functions in Host-Pathogen Interactions and Immunity to Diagnostic and Therapeutic Opportunities

Since their first description in the 1980s, exosomes, small endosomal-derived extracellular vesicles, have been involved in innate and adaptive immunity through modulating immune responses and mediating antigen presentation. Increasing evidence has reported the role of exosomes in host-pathogen inte...

Full description

Saved in:
Bibliographic Details
Published inReviews of physiology, biochemistry and pharmacology Vol. 172; p. 39
Main Authors Carrière, Jessica, Barnich, Nicolas, Nguyen, Hang Thi Thu
Format Journal Article
LanguageEnglish
Published Germany 01.01.2016
Subjects
Communicable Diseases - diagnosis
Communicable Diseases - metabolism
Communicable Diseases - therapy
Exosomes - metabolism
Host-Pathogen Interactions
Humans
Infectious diseases
Immune responses
Exosomes
Host-pathogen interactions
Online AccessGet more information

Cover

More Information
Summary:Since their first description in the 1980s, exosomes, small endosomal-derived extracellular vesicles, have been involved in innate and adaptive immunity through modulating immune responses and mediating antigen presentation. Increasing evidence has reported the role of exosomes in host-pathogen interactions and particularly in the activation of antimicrobial immune responses. The growing interest concerning exosomes in infectious diseases, their accessibility in various body fluids, and their capacity to convey a rich content (e.g., proteins, lipids, and nucleic acids) to distant recipient cells led the scientific community to consider the use of exosomes as potential new diagnostic and therapeutic tools. In this review, we summarize current understandings of exosome biogenesis and their composition and highlight the function of exosomes as immunomodulators in pathological states such as in infectious disorders. The potential of using exosomes as diagnostic and therapeutic tools is also discussed.
ISSN:0303-4240
DOI:10.1007/112_2016_7