Challenges and opportunities of pharmaceutical cocrystals: a focused review on non-steroidal anti-inflammatory drugs

The focus of the review is to discuss the relevant and essential aspects of pharmaceutical cocrystals in both academia and industry with an emphasis on non-steroidal anti-inflammatory drugs (NSAIDs). Although cocrystals have been prepared for a plethora of drugs, NSAID cocrystals are focused due to...

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Bibliographic Details
Published inMedChemComm Vol. 12; no. 5; pp. 75 - 721
Main Authors Garg, Utsav, Azim, Yasser
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 26.05.2021
RSC
Subjects
Analgesics
Anti-inflammatory agents
Bioavailability
Carcinogens
Chemistry
Drugs
Inflammation
Mechanical properties
Nonsteroidal anti-inflammatory drugs
Permeability
Pharmaceuticals
Physicochemical properties
Reviews
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Summary:The focus of the review is to discuss the relevant and essential aspects of pharmaceutical cocrystals in both academia and industry with an emphasis on non-steroidal anti-inflammatory drugs (NSAIDs). Although cocrystals have been prepared for a plethora of drugs, NSAID cocrystals are focused due to their humongous application in different fields of medication such as antipyretic, anti-inflammatory, analgesic, antiplatelet, antitumor, and anti-carcinogenic drugs. The highlights of the review are (a) background of cocrystals and other solid forms of an active pharmaceutical ingredient (API) based on the principles of crystal engineering, (b) why cocrystals are an excellent opportunity in the pharma industry, (c) common methods of preparation of cocrystals from the lab scale to bulk quantity, (d) some latest case studies of NSAIDs which have shown better physicochemical properties for example; mechanical properties (tabletability), hydration, solubility, bioavailability, and permeability, and (e) latest guidelines of the US FDA and EMA opening new opportunities and challenges. The focus of the review is to discuss the relevant and essential aspects of pharmaceutical cocrystals in both academia and industry with an emphasis on non-steroidal anti-inflammatory drugs (NSAIDs).
Bibliography:Dr. Yasser Azim was appointed in August 2009 as Assistant Professor in the Department of Applied Chemistry in Zakir Husain College of Engineering & Technology, Aligarh Muslim University, Aligarh, India. He completed his PhD in Chemistry at the Department of Chemistry, Aligarh Muslim University in 2006 and then joined the University of Hyderabad and later on the Indian Institute of Science, Bangalore as DST Young Scientist in the research laboratory of Prof. G.R. Desiraju. His current research interests include mechanochemical synthesis, crystal engineering, polymorphs and pharmaceutical cocrystals.
Utsav Garg joined the Ph.D. course at the Department of Applied Chemistry, Zakir Husain College of Engineering & Technology, Aligarh Muslim University in 2018. He obtained his B.Sc. (2015) and M.Sc. (2017) in industrial chemistry from Aligarh Muslim University and was awarded 'university medals' for securing 1st rank in both courses. He had qualified in the CSIR-UGC National Eligibility Test and is currently working as Junior Research Fellow under the supervision of Dr. Yasser Azim. His research interests are in crystal engineering, solid-state chemistry, metal organic frameworks and pharmaceutical cocrystals.
ISSN:2632-8682
2040-2503
2632-8682
2040-2511
DOI:10.1039/d0md00400f