Rapid desorption electrospray ionization-high resolution mass spectrometry method for the analysis of melamine migration from melamine tableware

• Published in: Talanta (Oxford) Vol. 101; pp. 453 - 459
• Main Authors: Mattarozzi, M., Milioli, M., Cavalieri, C., Bianchi, F., Careri, M.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 15.11.2012; Elsevier
• Subjects: Acetic acid; Analytical chemistry; Chemistry; Desorption; Desorption electrospray ionization-mass spectrometry; Exact sciences and technology; Food packaging material; Foods; Mass spectrometry; Melamine; Melamine tableware; Migration; Specific migration; Spectrometric and optical methods; Tableware; Specific migration; Melamine; Food packaging material; Desorption electrospray ionization-mass spectrometry; Melamine tableware; High resolution; Choice; Support; Tungsten V; Selectivity; Analyzer; Electrospray; Arsenic V; Improvement; Accuracy; Rapid technique; Detection limit; Release; Quantitative analysis; Coupled method; Sample; Use; Desorption; Exposure; Foodstuff; Concentration; Chemical ionization; Operating conditions; Parameter; Acetic acid; Reliability; Mass spectrometry
• ISSN: 0039-9140; 1873-3573
• DOI: 10.1016/j.talanta.2012.09.059

Migration of melamine into foods from melamine tableware has been object of recent Rapid Alert System for Food and Feed (RASFF) notifications. In this context, a rapid and sensitive desorption electrospray ionization-high resolution mass spectrometry (DESI-HRMS) method was developed and validated for the determination of melamine migration from plastic materials. The migration test was performed using acetic acid 3% (w/v) as food simulant. Evaluation of DESI parameters in terms of choice of support, motion profile, geometrical configuration and operating conditions coupled to the use of an orbitrap mass analyzer allowed to achieve significant improvements in terms of selectivity and accuracy obtaining detection and quantitation limits at low microgram per kilogram level. A LC–ESI-MS method was also developed for confirmatory purposes. Both methods were applied to 44 melamine tableware samples available on Italian market in order to assess their compliance with the law. Different concentration levels ranging from 0.00773±0.0006 to 3.0±0.1mg/kg were found after the third exposure to the simulant in new and used tableware with two samples out of 44 being characterized by a melamine release higher than the legal limit, i.e. 2.5mg/kg. A two tailed t-test allowed to assess the good agreement between the quantitative results obtained applying the DESI-MS method with those provided by LC–ESI-MS, thus proving reliability of DESI-HRMS as rapid technique for the study of melamine release from plastic materials. ► Rapid DESI-HRMS method for the study of melamine release from plastic materials. ► Linearity was assessed over two orders of magnitude. ► Analysis of many samples is feasible in a reduced time. ► High melamine concentration levels were found in melamine children's use tableware.