Elevated β-catenin and C-myc promote malignancy, relapse, and indicate poor prognosis in patients with relapsed glioma

• Published in: Journal of cancer research and therapeutics Vol. 18; no. 2; pp. 553 - 559
• Main Authors: Yu, Xuejuan, Xiao, Fengxia, Wei, Yuzhen, Miao, Lifeng, Zhang, Wei, Zhang, Xin, Wang, Dexiang
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.04.2022; Medknow Publications & Media Pvt. Ltd
• Subjects: Glioma; Medical prognosis; β-catenin; glioma; C-myc; malignancy; relapse; prognosis
• ISSN: 0973-1482; 1998-4138
• DOI: 10.4103/jcrt.jcrt_246_22

Context: Extensive studies have shown that β-catenin and C-myc have been linked to a number of human cancers. However, the role of β-catenin and C-myc in relapse glioma remains unclear. Aims: The aims of this study were to investigate the role of β-catenin and C-myc in relapsed glioma patients and to explore the possible impact of malignancy, relapse, and prognosis. Materials and Methods: We collected surgical samples of 100 patients with primary and relapsed glioma treated at our institution. Immunohistochemistry (IHC) staining was used to evaluate the expressions of β-catenin and C-myc. The impact of the differences on disease-free interval (DFI), initial overall survival (iOS), and overall survival from the time of glioma relapse (rOS) of the patients was analyzed. Kaplan-Meier survival functions were used to plot survival time, and a log-rank test was used for analyzing statistical significance. Cox multivariate regression analysis was used to determine independent prognostic parameters. Results: Compared to primary tumors, relapsed gliomas had higher expressions of β-catenin and C-myc (P < 0.05). Furthermore, the expressions of β-catenin and C-myc were significantly correlated with glioma grade (P < 0.05). These changes in expression at the time of relapse were independent of radiotherapy use. In multivariate Cox analysis, we found that β-catenin and C-myc were independent prognostic factors for rOS (P < 0.05). Conclusions: Elevated β-catenin and C-myc promote malignancy, relapse, and indicate poor prognosis in patients with relapsed glioma. The elevated levels of β-catenin and c-myc in relapsed glioma were not affected by radiation therapy. The results of this study may provide a new therapeutic target for patients with relapsed glioma.