Gender difference in cell-mediated immunity after thermal injury is mediated, in part, by elevated levels of interleukin-6

The gender difference in normal immune function has been well documented, however, there is only limited information regarding whether such a difference occurs after injury. To investigate this, we examined cell‐mediated immune responses in male and female mice given a 15% total body surface area do...

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Published inJournal of leukocyte biology Vol. 67; no. 3; pp. 319 - 326
Main Authors Gregory, Meredith S., Faunce, Douglas E., Duffner, Lisa A., Kovacs, Elizabeth J.
Format Journal Article
LanguageEnglish
Published United States Society for Leukocyte Biology 01.03.2000
Subjects
Animals
Antibodies - immunology
Antibodies - pharmacology
burn injury
Burns - immunology
Cell Division - drug effects
Concanavalin A - immunology
cytokine
Female
Hypersensitivity, Delayed - immunology
Immunity, Cellular - drug effects
Immunity, Cellular - immunology
Interleukin-6 - biosynthesis
Interleukin-6 - immunology
Lymphocyte Activation - drug effects
Lymphocyte Activation - immunology
macrophage
Macrophages - cytology
Macrophages - drug effects
Macrophages - immunology
Macrophages - metabolism
Male
Mice
Mice, Inbred BALB C
Sex Characteristics
Spleen - cytology
Spleen - drug effects
Spleen - immunology
Temperature
Time Factors
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Summary:The gender difference in normal immune function has been well documented, however, there is only limited information regarding whether such a difference occurs after injury. To investigate this, we examined cell‐mediated immune responses in male and female mice given a 15% total body surface area dorsal scald or sham injury. Both delayed‐type hypersensitivity (DTH) and splenocyte proliferative responses were significantly suppressed in males at 1 day and in females at 7 and 10 days post burn (P < 0.01). The decreased splenocyte proliferation was found to be macrophagedependent and suppression of both immune parameters corresponded with elevated interleukin‐6 (IL‐6) levels. Furthermore, post‐burn treatment with an anti‐IL‐6 antibody partially restored the DTH response in males at 1 day and females at 10 days post injury and completely restored splenocyte proliferation. These data demonstrate a possible mechanism for the gender difference in cell‐mediated immune responses after thermal injury. J. Leukoc. Biol. 67: 319–326; 2000.
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ISSN:0741-5400
1938-3673
DOI:10.1002/jlb.67.3.319