Sclerodermatous graft‐versus‐host disease: clinical spectrum and therapeutic challenges

• Published in: British journal of dermatology (1951) Vol. 156; no. 5; pp. 1032 - 1038
• Main Authors: White, J.M.L., Creamer, D., Du Vivier, A.W.P., Pagliuca, A., Ho, A.Y., Devereux, S., Salisbury, J.R., Mufti, G.J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.05.2007; Blackwell
• Subjects: Adult; Aged; Anemia, Refractory - surgery; Biological and medical sciences; Bone Marrow Transplantation - adverse effects; chronic graft‐versus‐host disease; clinical subtypes; Dermatology; Female; graft‐versus‐host disease; Hodgkin Disease - surgery; Humans; Immunosuppressive Agents - therapeutic use; Leukemia, Myeloid - surgery; Male; Medical sciences; Middle Aged; Plasmacytoma - surgery; PUVA Therapy; Recurrence; review; Scleroderma, Localized - classification; Scleroderma, Localized - etiology; Scleroderma, Localized - therapy; sclerodermatous graft‐versus‐host disease; Skin involvement in other diseases. Miscellaneous. General aspects; Stem Cell Transplantation - adverse effects; Thrombocytosis - surgery; treatment; Treatment Failure; Human; Immunopathology; Skin disease; Dermatology; Chronic disease; sclerodermatous graft-versus-host disease; chronic graft-versus-host disease; Graft versus host reaction; Case study; Symptomatology; Treatment; review; clinical subtypes; Sclerodermiform dermatosis; graft-versus-host disease

Summary Sclerodermatous graft‐versus‐host disease (GVHD) is a rare complication of bone marrow transplantation. While GVHD is often associated with the beneficial graft vs. tumour effect, it also contributes towards significant morbidity and mortality. No reliably effective treatment has yet been es...