European Task Force on Atopic Dermatitis (ETFAD): treatment targets and treatable traits in atopic dermatitis

• Published in: Journal of the European Academy of Dermatology and Venereology Vol. 34; no. 12; pp. e839 - e842
• Main Authors: Thyssen, J.P., Vestergaard, C., Deleuran, M., Bruin‐Weller, M.S., Bieber, T., Taieb, A., Seneschal, J., Cork, M.J., Paul, C., Flohr, C., Weidinger, S., Trzeciak, M., Werfel, T., Heratizadeh, A., Barbarot, S., Darsow, U., Simon, D., Torrelo, A., Chernyshov, P.V., Stalder, J.‐F., Gelmetti, C., Szalai, Z., Svensson, Å., Kobyletzki, L.B., De Raeve, L., Fölster‐Holst, R., Cristen‐Zaech, S., Hijnen, D., Gieler, U., Ring, J., Wollenberg, A.
• Format: Journal Article
• Language: English
• Published: England Wiley 01.12.2020
• Subjects: Advisory Committees; Clinical Medicine; Dermatitis, Atopic - drug therapy; Dermatologi och venereologi; Dermatology and Venereal Diseases; Eczema; Humans; Klinisk medicin; Life Sciences; Medical and Health Sciences; Medicin och hälsovetenskap; Patch Tests
• ISSN: 0926-9959; 1468-3083
• DOI: 10.1111/jdv.16716

Background: Surgery is a radical treatment for hidradenitis suppurativa (HS) and may be considered as the only one potentially curative. Objectives: To characterize HS recurrence in patients after surgery and assess the risk factors of recurrence. Methods: We conducted a monocentric retrospective cohort study. All consecutive patients who had surgery (January 1, 2012 to March 31, 2017) were included. We estimated the rate of recurrence of HS lesions after surgery (<1 cm from the scar), and recurrence-associated factors were analysed by univariate then multivariate logistic regression, estimating odds ratios (ORs) and 95% confidence intervals (CIs). Results: A total of 75 patients [median age 31.4 years (range 16–71); 36 females], corresponding to 115 interventions were included. The Hurley score at surgery was III for 70 (60%) patients. In total, 61/115 (53%) interventions involved wide excision and 50 (43%) limited local excision. The localizations were axillary folds (n = 46; 40%), buttocks (n = 15, 13%), genital area (n = 13; 11%), perineal area (n = 12; 10%) and inguinal folds (n = 18; 16%). We observed 11 (10%) complications and 40 (35%) recurrences. On multivariate analysis, probability of recurrence was associated with only one-stage surgical closure [OR 3.2 (95% CI 1.4–7.3), P = 0.005]. Overall, 44 (52%) patients were completely satisfied and 22 (26%) partially satisfied, and most (81%) considered the surgery the best treatment. Conclusions: Hidradenitis suppurativa recurrence in our study was 35% and associated with one-stage surgical closures, but two-thirds of patients were satisfied with surgical treatment and would recommend surgery.