Slow Calcium-dependent Inactivation of Depletion-activated Calcium Current. STORE-DEPENDENT AND -INDEPENDENT MECHANISMS

• Published in: The Journal of biological chemistry Vol. 270; no. 24; pp. 14445 - 14451
• Main Authors: Zweifach, Adam, Lewis, Richard S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16.06.1995; American Society for Biochemistry and Molecular Biology
• Subjects: Calcium - metabolism; Calcium Channel Blockers - metabolism; Cyclosporine - pharmacology; Ethers, Cyclic - pharmacology; Humans; Kinetics; Okadaic Acid; Phosphoprotein Phosphatases - antagonists & inhibitors; Tacrolimus - pharmacology; Tumor Cells, Cultured

Feedback regulation of Ca2+ release-activated Ca2+ (CRAC) channels was studied in Jurkat leukemic T lymphocytes using whole cell recording and [Ca2+]i measurement techniques. CRAC channels were activated by passively depleting intracellular Ca2+ stores in the absence of extracellular Ca2+. Under con...