Synthesis of (3′-5′), (2′-5′)-linked di- and tri-adenylyl methylphosphonate analogs

Stereoselectivity was found during the coupling reaction, to form 2′,5′- and 3′,5′-llnked di- and triadenylyl methyiphosphonate. The configuration of phosphorus was determined by 1HNMR NOE.

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Bibliographic Details
Published inNucleic acids research Vol. 21; no. 14; pp. 3245 - 3248
Main Authors Wang, Chun-guang, Wnag, Lai-xing, Yang, Xian-bin, Jiang, Tian-yi, Zhang, Li-he
Format Journal Article
LanguageEnglish
Published Oxford Oxford University Press 11.07.1993
Subjects
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
Genetic engineering
Genetic technics
Magnetic Resonance Spectroscopy
Methods. Procedures. Technologies
Molecular Conformation
Organophosphorus Compounds - chemical synthesis
Organophosphorus Compounds - chemistry
Synthetic digonucleotides and genes. Sequencing
Stereoselectivity
Oligonucleotide
Organic phosphonate
NMR spectrometry
N dimensional spectrometry
Chemical synthesis
Pulse sequence
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Summary:Stereoselectivity was found during the coupling reaction, to form 2′,5′- and 3′,5′-llnked di- and triadenylyl methyiphosphonate. The configuration of phosphorus was determined by 1HNMR NOE.
Bibliography:ark:/67375/HXZ-K0QP1LMP-3
istex:8C469679231C177BCFE6A10789D5ED85F8A08E40
ArticleID:21.14.3245
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ObjectType-Article-2
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ISSN:0305-1048
1362-4962
DOI:10.1093/nar/21.14.3245