Maternal deprivation of neonatal rats produces enduring changes in dopamine function

• Published in: Synapse (New York, N.Y.) Vol. 32; no. 1; pp. 37 - 43
• Main Authors: Hall, F.S., Wilkinson, L.S., Humby, T., Robbins, T.W.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.04.1999
• Subjects: 3,4-Dihydroxyphenylacetic Acid - metabolism; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal - physiology; d-amphetamine; Dextroamphetamine - pharmacology; dopamine; Dopamine - metabolism; Dopamine - physiology; Homovanillic Acid - metabolism; Hydroxyindoleacetic Acid - metabolism; Maternal Deprivation; Microdialysis; nucleus accumbens; Nucleus Accumbens - drug effects; Nucleus Accumbens - metabolism; Potassium - pharmacology; Rats; Social Isolation; Space life sciences

Isolation‐rearing of weanling rats produces a syndrome of behavioral and neurochemical effects that are indicative of enhanced ventrostriatal dopamine function observed in adulthood. By contrast, maternal deprivation of neonatal rats decreases behavioral responses to dopamine agonists when tested in...