Maternal deprivation of neonatal rats produces enduring changes in dopamine function
Isolation‐rearing of weanling rats produces a syndrome of behavioral and neurochemical effects that are indicative of enhanced ventrostriatal dopamine function observed in adulthood. By contrast, maternal deprivation of neonatal rats decreases behavioral responses to dopamine agonists when tested in...
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Published in | Synapse (New York, N.Y.) Vol. 32; no. 1; pp. 37 - 43 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
New York
John Wiley & Sons, Inc
01.04.1999
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Subjects | |
Online Access | Get full text |
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Summary: | Isolation‐rearing of weanling rats produces a syndrome of behavioral and neurochemical effects that are indicative of enhanced ventrostriatal dopamine function observed in adulthood. By contrast, maternal deprivation of neonatal rats decreases behavioral responses to dopamine agonists when tested in adults, which may indicate the opposite situation. However, in the present study it is reported that in vivo microdialysis of the nucleus accumbens (NAC) revealed enhanced release of dopamine (DA) in response to both d‐amphetamine and high K+ perfusate in maternally deprived subjects. Thus, behavioral responses to d‐amphetamine are diminished in maternally deprived rats despite apparent increases in presynaptic dopaminergic function in the NAC. Synapse 32:37–43, 1999. © 1999 Wiley‐Liss, Inc. |
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Bibliography: | National Institute of Drug Abuse ArticleID:SYN5 ark:/67375/WNG-XGH16SC2-V Wellcome Trust Mac Arthur Foundation istex:EBBC07140E4C5AB463C1C5E79C7602200FC60839 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0887-4476 1098-2396 |
DOI: | 10.1002/(SICI)1098-2396(199904)32:1<37::AID-SYN5>3.0.CO;2-4 |