Glucose transporter 1 expression in canine osteosarcoma
Hypoxia in tumours has been associated with an increased resistance to radiation and chemotherapy, and increased metastatic potential. Hypoxia-inducible factor 1-α (HIF-1α) is a transcription factor induced by hypoxia. Glucose transporter 1 (GLUT-1), a downstream product of HIF-1α pathway activation...
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Published in | Veterinary & comparative oncology Vol. 6; no. 2; pp. 133 - 140 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Oxford, UK : Blackwell Publishing Ltd
01.06.2008
Blackwell Publishing Ltd |
Subjects | |
Online Access | Get full text |
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Summary: | Hypoxia in tumours has been associated with an increased resistance to radiation and chemotherapy, and increased metastatic potential. Hypoxia-inducible factor 1-α (HIF-1α) is a transcription factor induced by hypoxia. Glucose transporter 1 (GLUT-1), a downstream product of HIF-1α pathway activation, is over-expressed in a variety of human tumours. The purpose of this study was to determine if GLUT-1 is expressed in canine osteosarcomas (OSAs) and if the expression is related to tumour necrosis and outcome. Immunohistochemistry was performed on 44 histologically confirmed OSA tissue samples to assess expression of GLUT-1. Of 44 cases, 27 (61%) expressed GLUT-1. There was no statistical correlation between GLUT-1 and disease-free interval, survival time or percentage of necrosis. As hypothesized, GLUT-1 is present in canine appendicular OSAs. A more objective evaluation of GLUT-1 and other proteins in the HIF-1α pathway may be warranted. |
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Bibliography: | http://dx.doi.org/10.1111/j.1476-5829.2007.00155.x ark:/67375/WNG-Q4103K07-S ArticleID:VCO155 istex:4008268D22B3794076B4AFE2C7892EB5C78F8C8C ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1476-5810 1476-5829 |
DOI: | 10.1111/j.1476-5829.2007.00155.x |