Imaging of water and fat fractions in high-field MRI with multiple slice chemical shift-selective inversion recovery

• Published in: Journal of magnetic resonance imaging Vol. 12; no. 3; pp. 488 - 496
• Main Authors: Laurent, W.M., Bonny, J.M., Renou, J.P.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.09.2000; Wiley-Blackwell
• Subjects: Adipose Tissue - chemistry; Animals; Cattle; Chemical and Process Engineering; Engineering Sciences; fat/water imaging; Food engineering; high field; Life Sciences; Lipids - analysis; Magnetic Resonance Imaging - methods; Magnetics; Models, Theoretical; muscle; Muscle, Skeletal - chemistry; quantitative imaging; Regression Analysis; Reproducibility of Results; Sensitivity and Specificity; Water - analysis; RESONNANCE MAGNETIQUE
• ISSN: 1053-1807; 1522-2586
• DOI: 10.1002/1522-2586(200009)12:3<488::AID-JMRI15>3.0.CO;2-5

Fat and water fractions were quantified at high field using a chemical shift‐selective inversion recovery (CSS‐IR) sequence to address the major difficulties encountered at high field by phase‐sensitive techniques used for fat/water discrimination. Water‐ and fat‐suppressed images were perfectly registered, which is a prerequisite for quantification. Immunity of the inversion pulse to B1 field modulations and off‐resonance effects was tested for two adiabatic inversion pulses, with hyperbolic secant and asymmetric hyper‐pulse waveforms. Taking into account adiabaticity, immunity to off‐resonance, radiofrequency power requirements, and specific absorption rate, the former was chosen. A close correlation was found between fat content measured by CSS‐IR at 4.7 T (R2= 0.97, P < 0.001) and 9.4 T (R2= 0.99, P < 0.05) and that measured by Soxhlet extraction. Different sources of bias (lowsignal‐to‐noise ratio, magnetization transfer effect) are discussed. J. Magn. Reson. Imaging 2000;12:488–496. © 2000 Wiley‐Liss, Inc.