Low-dose oral tri-iodothyronine does not directly increase food intake in man

• Published in: Diabetes, obesity & metabolism Vol. 9; no. 3; pp. 435 - 437
• Main Authors: Martin, N.M, Small, C.J, Lee, J.L, Ellis, S, Dhillo, W.S, Smith, K.L, Kong, W.M, Frost, G.S, Bloom, S.R
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.05.2007; Blackwell Publishing Ltd
• Subjects: Administration, Oral; Adult; appetite; Cross-Over Studies; Double-Blind Method; Eating - drug effects; Eating - physiology; energy expenditure; Energy Intake - physiology; Energy Metabolism - physiology; food intake; Humans; Male; Thyrotropin - blood; thyroxine; tri-iodothyronine; Triiodothyronine - administration & dosage; Triiodothyronine - blood
• ISSN: 1463-1326; 1462-8902; 1463-1326
• DOI: 10.1111/j.1463-1326.2006.00613.x

Previously, we have shown that low-dose tri-iodothyronine (T3) increases food intake in rodents. This randomised, double-blind, placebo-controlled study aimed to investigate the effects of low-dose T3 on food intake in normal body weight individuals. However, despite an elevation in fT3 comparable to our earlier studies, administration of low-dose T3 in the fasted state did not stimulate food intake in man.