Real‐world outcomes of advanced melanoma patients not represented in phase III trials

• Published in: International journal of cancer Vol. 147; no. 12; pp. 3461 - 3470
• Main Authors: Zeijl, Michiel C. T., Ismail, Rawa K., Wreede, Liesbeth C., Eertwegh, Alfonsus J. M., Boer, Anthonius, Dartel, Maaike, Hilarius, Doranne L., Aarts, Maureen J. B., Berkmortel, Franchette W. P. J., Boers‐Sonderen, Marye J., Groot, Jan‐Willem B., Hospers, Geke A. P., Kapiteijn, Ellen, Piersma, Djura, Rijn, Rozemarijn S., Suijkerbuijk, Karijn P. M., ten Tije, Albert J., Veldt, Astrid A. M., Vreugdenhil, Gerard, Haanen, John B. A. G., Wouters, Michel W. J. M
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 15.12.2020; Wiley Subscription Services, Inc
• Subjects: Adult; advanced melanoma; Aged; Aged, 80 and over; Antineoplastic Agents, Immunological - therapeutic use; Cancer; Cancer Therapy and Prevention; Clinical Decision-Making; Clinical trials; Clinical Trials, Phase III as Topic; Decision making; decision tree; Female; Humans; ineligibility; L-Lactate dehydrogenase; Lactic acid; Male; Medical prognosis; Medical research; Melanoma; Melanoma - drug therapy; Melanoma - pathology; Metastases; Middle Aged; Molecular Targeted Therapy - methods; Neoplasm Staging; Netherlands; Oncology; Patient Selection; Prognosis; Proportional Hazards Models; Prospective Studies; real‐world outcomes; Survival; Survival Analysis; Treatment Outcome; Young Adult; Netherlands; decision tree; real-world outcomes; advanced melanoma; survival; ineligibility
• ISSN: 0020-7136; 1097-0215
• DOI: 10.1002/ijc.33162

The aim was to provide evidence on systemically treated patients with advanced melanoma not represented in phase III trials to support clinical decision‐making. Analysis were performed on advanced melanoma patients diagnosed between 2014 and 2017 in the Netherlands, treated with immune‐ or targeted therapy, who met ≥1 trial exclusion criteria. These criteria were derived from the KEYNOTE‐006 and CHECKMATE‐067/‐066 phase III trials. Prognostic importance of factors associated with overall survival (OS) was assessed with the Kaplan‐Meier method, Cox models, predicted OS probabilities of prognostic subgroups and a conditional inference survival tree (CIST). A nationwide population‐based registry was used as data source. Of 2536 systemically treated patients with advanced melanoma, 1004 (40%) patients were ineligible for phase IIII trials. Ineligible patients had a poorer median OS (mOS) compared to eligible patients (8.8 vs 23 months). Eligibility criteria strongly associated with OS in systemically treated ineligible patients were Eastern Cooperative Oncology Group Performance Score (ECOG PS) ≥2, brain metastases (BM) and lactate dehydrogenase (LDH) of >500 U/L. Patients with ECOG PS of ≥2 with or without symptomatic BM had a predicted mOS of 6.5 and 11.3 months and a 3‐year survival probability of 9.3% and 23.6%, respectively. The CIST showed the strongest prognostic covariate for survival was LDH, followed by ECOG PS. The prognosis of patients with LDH of >500 U/L is poor, but long‐term survival is possible. The prognosis of ineligible patients with advanced melanoma in real‐world was very heterogeneous and highly dependent on LDH value, ECOG PS and symptomatic BM. What's new? By necessity, randomized controlled trials (RCTs) exclude many patients. However, these ineligible patients are often still treated with new systemic therapies on an individual basis. In this study, the authors examined how various subgroups of ineligible patients fared following treatment for advanced melanoma. They found that several criteria were strongly associated with prognosis in these patients, including lactate dehydrogenase (LDH) levels. These results should provide clinicians with a decision tree of prognostic factors to help guide treatment decisions.