Predictors of 30-day morbidity and mortality in transnasal microscopic pituitary tumor excision

• Published in: International forum of allergy & rhinology Vol. 6; no. 2; pp. 206 - 213
• Main Authors: Lawrence, Lauren A., Baker, Andrew B., Nguyen, Shaun A., Karnezis, Tom T., Soler, Zachary M., Schlosser, Rodney J.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.02.2016; Wiley Subscription Services, Inc
• Subjects: Adolescent; Adult; adverse events; Age Factors; Aged; Aged, 80 and over; anterior skull base; Body mass index; endonasal approach to the pituitary; Endoscopy; Female; Humans; Male; Middle Aged; Morbidity; Mortality; NSQIP; outcomes; Paranasal Sinuses - surgery; Pituitary Neoplasms - diagnosis; Pituitary Neoplasms - mortality; Pituitary Neoplasms - surgery; postoperative; Postoperative Complications - diagnosis; Postoperative Complications - mortality; Postoperative period; Reoperation; Risk; Sepsis; Surgical outcomes; Survival Analysis; Treatment Outcome; Young Adult; postoperative; NSQIP; adverse events; endonasal approach to the pituitary; outcomes; anterior skull base
• ISSN: 2042-6976; 2042-6984
• DOI: 10.1002/alr.21641

Background There is a lack of population‐based, multi‐institutional analyses of factors associated with morbidity and mortality following pituitary tumor excision. Methods The American College of Surgeons National Surgical Quality Improvement Project files were used to compile information on patients that had undergone transnasal microscopic pituitary tumor resection from 2006 to 2012. Patient demographics, comorbidities, operative characteristics, and morbidity and mortality in the 30 days following surgery were included. Multivariate logistic regression was used for categorical variables and multivariate linear regression was used for continuous variables to evaluate factors leading to adverse events. Results A total of 658 patients were included, of which 58 (8.81%) experienced a complication, reoperation or death in the 30 days following surgery. The most common complications were reoperation (3.37%), followed by unplanned reintubation (1.99%), urinary tract infection (1.68%), and transfusion (1.68%). Predictors of any complication, reoperation, or death include preoperative sepsis (odds ratio [OR] = 7.596) and lower preoperative serum albumin (OR = 6.667). Younger age predicted surgical complications (OR = 1.105). Predictors of medical complications include higher body mass index (OR = 1.112), chronic steroid use (OR = 6.568), preoperative sepsis (OR = 15.297), and lower preoperative serum hematocrit (OR = 1.225). Predictors of increased total length of hospital stay were older age (β = 0.146), higher body mass index (β = 0.188), chronic steroid use (β = 0.142), preoperative sepsis (β = 0.489), and lower preoperative serum albumin (β = −0.213). Conclusion Although adverse events following pituitary tumor excision are low, awareness of factors associated with morbidity and mortality in the early postoperative period may allow for improved patient monitoring and outcomes.