Functional and structural aspects of the kell blood group system

Two covalently linked proteins, Kell and XK, constitute the Kell blood group system. Kell, a 93-Kd type II glycoprotein, is highly polymorphic and carries all but 1 of the known Kell antigens, and XK, which traverses the membrane 10 times, carries a single antigen, the ubiquitous Kx. The Kell/XK com...

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Published inTransfusion medicine reviews Vol. 14; no. 2; pp. 93 - 103
Main Authors Lee, Soohee, Russo, David, Redman, Colvin
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2000
Subjects
Amino Acid Sequence
Amino Acid Transport Systems, Neutral
Carrier Proteins - chemistry
Carrier Proteins - genetics
Endothelin-3 - chemistry
Endothelin-3 - metabolism
Humans
Kell Blood-Group System - chemistry
Kell Blood-Group System - genetics
Kell Blood-Group System - physiology
Membrane Proteins - chemistry
Membrane Proteins - genetics
Molecular Sequence Data
Neprilysin
Phenotype
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Summary:Two covalently linked proteins, Kell and XK, constitute the Kell blood group system. Kell, a 93-Kd type II glycoprotein, is highly polymorphic and carries all but 1 of the known Kell antigens, and XK, which traverses the membrane 10 times, carries a single antigen, the ubiquitous Kx. The Kell/XK complex is not limited to erythroid tissues and may have multiple physiological roles. Absence of one of the component proteins, XK, is associated with abnormal red cell morphology and late-onset forms of nerve and muscle abnormalities, whereas the other protein component, Kell, is an enzyme whose principal known function is the production of a potent bioactive peptide, ET-3.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0887-7963
1532-9496
DOI:10.1016/S0887-7963(00)80001-2