Moderate calorie restriction attenuates age‑associated alterations and improves cardiac function by increasing SIRT1 and SIRT3 expression

• Published in: Molecular medicine reports Vol. 18; no. 4; pp. 4087 - 4094
• Main Authors: Yu, Wei, Qin, Jinjin, Chen, Chunjuan, Fu, Yucai, Wang, Wei
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.10.2018; Spandidos Publications UK Ltd
• Subjects: Age; Aging - metabolism; Animals; Autophagy; Blood pressure; Body Weight; Caloric Restriction; Cardiac function; Cardiomyocytes; Cardiovascular disease; Disease age factors; Female; Gene expression; Health aspects; Heart; Heart - physiology; Heart Function Tests; Heart rate; Heart Ventricles - anatomy & histology; Heart Ventricles - metabolism; High fat diet; Immunoblotting; Insulin; Intra-Abdominal Fat - metabolism; Laboratory animals; Life span; Lipoproteins, LDL - metabolism; Low density lipoprotein; Myocardium; Nutrient deficiency; Obesity; Organ Size; Physiological aspects; Proteins; Rats, Sprague-Dawley; Reducing diets; Rodents; Signaling peptides and proteins; SIRT1 protein; Sirtuin 1 - metabolism; Sirtuin 3 - metabolism; Sirtuins; Studies; Triglycerides - metabolism; Ventricle; Ventricular Function; United States > US

Calorie restriction (CR) extends the lifespan of mammals and improves cardiac function by attenuation of age‑associated alterations. Sirtuins (SIRT) are involved in these mechanisms, however, the extent to which CR affects cardiac function and sirtuin expression remains unknown. Therefore, the prese...