Striatal Acetylcholine–Dopamine Imbalance in Parkinson Disease: In Vivo Neuroimaging Study with Dual-Tracer PET and Dopaminergic PET–Informed Correlational Tractography

• Published in: Journal of Nuclear Medicine Vol. 63; no. 3; pp. 438 - 445
• Main Authors: Sanchez-Catasus, Carlos A., Bohnen, Nicolaas I., D’Cruz, Nicholas, Müller, Martijn L.T.M.
• Format: Journal Article
• Language: English
• Published: United States Society of Nuclear Medicine 01.03.2022
• Subjects: Acetylcholine; Animal models; Animals; Anisotropy; Cerebral hemispheres; Cholinergics; Clinical Investigation; Clusters; Dopamine; Dopamine receptors; Female; Fluorine isotopes; Humans; In vivo methods and tests; Integrity; Medical imaging; Movement disorders; Neostriatum; Neurodegenerative diseases; Neuroimaging; Parkinson Disease - complications; Parkinson Disease - diagnostic imaging; Parkinson's disease; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Substantia alba; Tomography; Parkinson disease; dopaminergic nigrostriatal connectivity; acetylcholine–dopamine imbalance; 18F-FEOBV PET; 11C-DTBZ PET

Previous studies of animal models of Parkinson disease (PD) suggest an imbalance between striatal acetylcholine and dopamine, although other studies have questioned this. To our knowledge, there are no previous in vivo neuroimaging studies examining striatal acetylcholine-dopamine imbalance in PD pa...