The differences in the expression of fractalkine and its receptor in conditions of tonsillar hypertrophy and chronic tonsillitis

• Published in: Auris, nasus, larynx Vol. 46; no. 4; pp. 565 - 569
• Main Authors: Koclu Hetemoglu, Elif, Turkoglu Babakurban, Seda, Terzi, Yunus Kasım, Sahin, Feride Iffet, Erbek, Selim Sermed
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2019
• Subjects: Adenoidectomy; Adenoids - metabolism; Adenoids - pathology; Adenoids - surgery; Chemokine CX3CL1 - metabolism; Child; Child, Preschool; Chronic Disease; Chronic tonsillitis; CX3C Chemokine Receptor 1 - genetics; CX3C Chemokine Receptor 1 - metabolism; Female; Fractalkine expression; Humans; Hypertrophic tonsil; Hypertrophy; Male; Palatine Tonsil - metabolism; Palatine Tonsil - pathology; Palatine Tonsil - surgery; Polymorphism, Single Nucleotide; Tonsillectomy; Tonsillitis - metabolism; Tonsillitis - surgery; Chronic tonsillitis; Hypertrophic tonsil; Fractalkine expression
• ISSN: 0385-8146; 1879-1476; 1879-1476
• DOI: 10.1016/j.anl.2018.12.001

Fractalkine, member of chemokine family, is involved in many inflammatory processes in the human body. The aim of this study is to compare expression levels of fractalkine ligand and its receptor in chronic tonsillitis and hypertrophic tonsil samples. The study was conducted at Baskent University Departments of Otorhinolaryngology and Medical Genetics. It is designed as a prospective, non-randomized, controlled clinical study. Total 97 samples, obtained from adenotonsillectomy due to chronic tonsillitis or tonsillar hypertrophy, were participated in the study. Fractalkine and its receptor expression levels were determined and comparison was made between the tissue groups. c.839C>T (T280M) polymorphism of fractalkine receptor was analyzed, then relationship between polymorphism and the expression level of fractalkine receptor was investigated. Fractalkine receptor expression was significantly higher in the hypertrophic tonsil group than chronic tonsillitis group (p<0.05). Fractalkine, member of chemokine family, and its receptor may play role in preventing chronic-recurrent tonsillitis.