Quadrupole magnetic field-flow fractionation: A novel technique for the characterization of magnetic nanoparticles

• Published in: Journal of magnetism and magnetic materials Vol. 311; no. 1; pp. 383 - 387
• Main Authors: Carpino, Francesca, Zborowski, Maciej, Stephen Williams, P.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 01.04.2007; Elsevier Science
• Subjects: Biological and medical sciences; Biotechnology; Field-flow fractionation; Fundamental and applied biological sciences. Psychology; Magnetic field-flow fractionation (MgFFF); Magnetic nanoparticles; Methods. Procedures. Technologies; Nanoparticle characterization; Others; Quadrupole magnetic field; Various methods and equipments; Field-flow fractionation; Quadrupole magnetic field; Magnetic field-flow fractionation (MgFFF); Nanoparticle characterization; Magnetic nanoparticles; Fractionation; Iron oxide; Nanoparticle; Dextran derivatives; Biological marker; Magnetic field effect; Magnetic particles; Magnetite; Coated particle
• ISSN: 0304-8853
• DOI: 10.1016/j.jmmm.2006.11.162

Quadrupole magnetic field-flow fractionation (MgFFF) is an analytical separation and characterization technique for nano- and micro-sized magnetic particles. It fractionates particles according to their content of magnetite or other magnetic material. The potential and versatility of MgFFF for separation and characterization of magnetic nanoparticles, such as those used for immunospecific labeling of biological cells for magnetic separation, is demonstrated. A broadly polydisperse sample of dextran-coated magnetite nanoparticles was eluted under programmed field decay conditions, and quantitative data concerning the distribution of magnetite content were determined from the elution profile using a data reduction method.