Rhodomollosides A and B, glycosides of methyl everninate from the aerial parts of Rhododendron molle

• Published in: Journal of asian natural products research Vol. 24; no. 11; pp. 1025 - 1032
• Main Authors: Yang, Xue-Rong, Tanaka, Naonobu, Song, Jing-Ru, Lu, Feng-Lai, Yan, Xiao-Jie, Li, Jian-Xing, Zhao, Xue-Ying, Kashiwada, Yoshiki, Li, Dian-Peng
• Format: Journal Article
• Language: English
• Published: ABINGDON Taylor & Francis 02.11.2022; Taylor & Francis Ltd
• Subjects: allose; Chemistry; Chemistry, Applied; Chemistry, Medicinal; Cytotoxicity; D-allose; Eriaceae; Glycosides; glycosides of methyl everninate; Herbal medicine; Life Sciences & Biomedicine; Lipopolysaccharides; Macrophages; Medicinal plants; mice; moieties; Monosaccharides; Pharmacology & Pharmacy; Physical Sciences; Plant Sciences; Rhododendron; Rhododendron molle; rhodomollosides A and B; Science & Technology; spectroscopy; Sugar; Toxicity; glycosides of methyl everninate; Eriaceae; DITERPENOIDS; Rhododendron molle; rhodomollosides A and B; D-allose; FLOWERS
• ISSN: 1028-6020; 1477-2213; 1477-2213
• DOI: 10.1080/10286020.2021.2011241

Two new glycosides of methyl everninate, rhodomollosides A (1) and B (2), were isolated from the aerial parts of a medicinal plant Rhododendron molle. The structures of 1 and 2 were elucidated on the basis of detailed spectroscopic analyses as well as HPLC analyses for thiazolidine derivatives of their sugar moieties. The sugar moiety of rhodomolloside A (1) was elucidated to be a rare monosaccharide, D-allose, while rhodomolloside B (2) was assigned as a D-glucoside of methyl everninate. Furthermore, they were evaluated for their cytotoxicity against RAW264.7 cells, and for their inhibitory effects with a lipopolysaccharide (LPS)-stimulated murine macrophages RAW 264.7 cells model.