Cutaneous malakoplakia

Malakoplakia is an acquired granulomatous disorder first described by Michaelis and Gutmann in 1902. The pathogenesis of malakoplakia is poorly understood, but it is thought to be secondary to an acquired bacteriocidal defect in macrophages occurring mostly in immunosuppressed patients or in the set...

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Published inArchives of pathology & laboratory medicine (1976) Vol. 132; no. 1; pp. 113 - 117
Main Authors Kohl, Shane K, Hans, Christine P
Format Journal Article
LanguageEnglish
Published United States College of American Pathologists 01.01.2008
Subjects
Anti-Bacterial Agents - therapeutic use
Antibiotics
Bacterial Infections - microbiology
Bacterial Infections - pathology
Biopsy
Bladder
Care and treatment
Case studies
Combined Modality Therapy
Diagnosis
E coli
Health aspects
Humans
Immune system
Immunocompromised Host
Inflammation
Macrophages - pathology
Malacoplakia - etiology
Malacoplakia - pathology
Malacoplakia - therapy
Microorganisms
Neutrophils
Pathogenesis
Prognosis
Skin diseases
Skin Diseases, Infectious - microbiology
Skin Diseases, Infectious - pathology
Skin Diseases, Infectious - therapy
Transplants & implants
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Summary:Malakoplakia is an acquired granulomatous disorder first described by Michaelis and Gutmann in 1902. The pathogenesis of malakoplakia is poorly understood, but it is thought to be secondary to an acquired bacteriocidal defect in macrophages occurring mostly in immunosuppressed patients or in the setting of autoimmune disease. Malakoplakia has been described in numerous anatomic locations, most commonly in the genitourinary tract. Microscopically, malakoplakia consists predominantly of sheets of macrophages known as von Hansemann cells with scattered targetoid intracytoplasmic inclusions known as Michaelis-Gutmann bodies. Cutaneous malakoplakia is a rare entity with less than 50 cases reported in the literature. In this article, we review cutaneous malakoplakia including the clinical, gross, and microscopic features as well as the treatment and prognosis of 40 cases of cutaneous malakoplakia identified in the literature.
ISSN:0003-9985
1543-2165
1543-2165
DOI:10.5858/2008-132-113-cm