The antifungal metabolites from coculture of Aspergillus fumigatus and Alternaria alternata associated with Coffea arabica

One new cyclohexenone derivative, asperfumtone A (1) along with six known compounds were obtained from the coculture of Aspergillus fumigatus and Alternaria alternata associated with Coffea arabica. The configuration of 2 was first reported in the research. The structures were determined by extensiv...

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Published inNatural product research Vol. 38; no. 5; pp. 753 - 758
Main Authors Wu, Ya-Mei, Yang, Xue-Qiong, Yang, Ya-Bin, Cai, Le, He, Fei-Fei, Ding, Zhong-Tao
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 03.03.2024
Taylor & Francis Ltd
Subjects
Alternaria alternata
antifungal
Aspergillus fumigatus
co-culture
coculture
Coffea arabica
Coffee
Fungicides
Fusarium incarnatum
metabolite
Metabolites
plant pathogens
spectroscopy
antifungal
metabolite
Alternaria alternata
Coffea arabica
Aspergillus fumigatus
co-culture
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Summary:One new cyclohexenone derivative, asperfumtone A (1) along with six known compounds were obtained from the coculture of Aspergillus fumigatus and Alternaria alternata associated with Coffea arabica. The configuration of 2 was first reported in the research. The structures were determined by extensive spectroscopic analyses, and ECD calculation. Compounds 3, 4 and 7 showed significant antifungal activities against coffee phytopathogens A. alternata and Fusarium incarnatum with MICs of 1 μg/mL. Compounds 1 and 2 showed weak antifungal activities against A. alternata and F. incarnatum with MICs of 32-64 μg/mL.
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ISSN:1478-6419
1478-6427
1478-6427
DOI:10.1080/14786419.2023.2196722