A brief journey through the immune system

This review serves as an introduction to an Immunology Series for the Nephrologist published in CJASN. It provides a brief overview of the immune system, how it works, and why it matters to kidneys. This review describes in broad terms the main divisions of the immune system (innate and adaptive), t...

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Bibliographic Details
Published inClinical journal of the American Society of Nephrology Vol. 10; no. 7; pp. 1274 - 1281
Main Authors Yatim, Karim M, Lakkis, Fadi G
Format Journal Article
LanguageEnglish
Published United States American Society of Nephrology 01.07.2015
Subjects
Adaptive Immunity
Animals
Biological Evolution
Humans
Immune System - immunology
Immune System - physiopathology
Immunity, Innate
Kidney - immunology
Kidney - physiopathology
Kidney Diseases - immunology
Kidney Diseases - physiopathology
Lymphocytes - immunology
Lymphoid Tissue - immunology
Renal Immunology
ARF
immunology
renal transplantation
tolerance
GN
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Summary:This review serves as an introduction to an Immunology Series for the Nephrologist published in CJASN. It provides a brief overview of the immune system, how it works, and why it matters to kidneys. This review describes in broad terms the main divisions of the immune system (innate and adaptive), their cellular and tissue components, and the ways by which they function and are regulated. The story is told through the prism of evolution in order to relay to the reader why the immune system does what it does and why imperfections in the system can lead to renal disease. Detailed descriptions of cell types, molecules, and other immunologic curiosities are avoided as much as possible in an effort to not detract from the importance of the broader concepts that define the immune system and its relationship to the kidney.
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ISSN:1555-9041
1555-905X
DOI:10.2215/CJN.10031014