Prospective Trial of Infrapopliteal Artery Balloon Angioplasty for Critical Limb Ischemia: Angiographic and Clinical Results
To evaluate the safety and efficacy of infrapopliteal percutaneous transluminal angioplasty (PTA) as a primary treatment of chronic critical limb ischemia in a prospective trial. Infrapopliteal PTA was performed on 72 limbs of 60 patients (mean age, 72 y; range, 38–92 y) and patients were followed f...
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Published in | Journal of vascular and interventional radiology Vol. 11; no. 8; pp. 1021 - 1031 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.09.2000
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Subjects | |
Online Access | Get full text |
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Summary: | To evaluate the safety and efficacy of infrapopliteal percutaneous transluminal angioplasty (PTA) as a primary treatment of chronic critical limb ischemia in a prospective trial.
Infrapopliteal PTA was performed on 72 limbs of 60 patients (mean age, 72 y; range, 38–92 y) and patients were followed for 12–24 months.
The primary angiographic success rate for the stenoses was 84% (102 of 121) and that for the occlusions was 61% (41 of 67) with corresponding restenosis rates of 32% and 52% at follow-up angiography performed a mean of 10 months after primary PTA. The rate of major complications was 2.8% (access site pseudoaneurysms in two patients). The primary clinical success was 63% (45 of 72). A 48% cumulative primary patency rate, a 56% secondary patency rate, and a 80% cumulative limb salvage rate were registered at 18 months, as determined with use of Kaplan-Meier analysis. Lack of angiographic improvement at the site of the most severe ischemia and renal insufficiency (serum creatinine level > 130 mmol/L) were independent predictors of poorer long-term clinical results, as determined with use of Cox multiple regression analysis.
Infrapopliteal PTA is a feasible primary treatment of chronic critical limb ischemia with moderate primary angiographic and clinical success, a low complication rate, and a cumulative limb salvage rate comparable with surgical techniques. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1051-0443 1535-7732 |
DOI: | 10.1016/S1051-0443(07)61332-3 |