A systematic review of synthetic tyrosinase inhibitors and their structure-activity relationship

• Published in: Critical reviews in food science and nutrition Vol. 62; no. 15; pp. 4053 - 4094
• Main Authors: Peng, Zhiyun, Wang, Guangcheng, Zeng, Qiao-Hui, Li, Yufeng, Liu, Haiquan, Wang, Jing Jing, Zhao, Yong
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 2022; Taylor & Francis Ltd
• Subjects: Antibacterial agents; Antibiotic resistance; Antibiotics; Antiinfectives and antibacterials; Chemical compounds; Cytotoxicity; Enzymes; Inhibitors; Insecticide resistance; Insecticides; Melanin; Microorganisms; molecular docking; Neurodegeneration; neurodegenerative diseases; nutrition; Oxidation; Pharmaceutical industry; Pharmacology; Sclerotization; Skin resistance; structure-activity relationship; structure-activity relationships; synthetic compounds; systematic review; Therapeutic targets; therapeutics; Toxicity; Tyrosinase; Tyrosinase inhibitors; Tyrosinase inhibitors; synthetic compounds; molecular docking; structure-activity relationship

Tyrosinase is a copper-containing oxidation enzyme, which is responsible for the production of melanin. This enzyme is widely distributed in microorganisms, animals and plants, and plays an essential role in undesirable browning of fruits and vegetables, antibiotic resistance, skin pigment formation...