Relapsed Babesia microti Infection Following Allogeneic Hematopoietic Cell Transplantation in a Patient With B-cell Acute Lymphoblastic Leukemia: Case Report and Review of the Literature

Abstract A patient with relapsed/refractory B-cell acute lymphoblastic leukemia developed babesiosis before allogeneic hematopoietic cell transplantation while on atovaquone for Pneumocystis jirovecii pneumonia prophylaxis. Despite receiving a prolonged course of atovaquone and azithromycin until wh...

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Published inOpen forum infectious diseases Vol. 8; no. 9
Main Authors Rosenblatt, Joshua, Leung, Annie, Baneman, Emily, Fuller, Risa, Taimur, Sarah, Paniz-Mondolfi, Alberto E, Malone, Adriana K, Kirkman, Laura, Jacobs, Samantha E
Format Journal Article
LanguageEnglish
Published US Oxford University Press 01.09.2021
Subjects
ID Teaching Cases
babesiosis
hematopoietic cell transplantation
tick-borne pathogens
immunocompromised host
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Summary:Abstract A patient with relapsed/refractory B-cell acute lymphoblastic leukemia developed babesiosis before allogeneic hematopoietic cell transplantation while on atovaquone for Pneumocystis jirovecii pneumonia prophylaxis. Despite receiving a prolonged course of atovaquone and azithromycin until whole-blood Babesia microti DNA was no longer detected by polymerase chain reaction, her post-transplant course was complicated by relapsed babesiosis. We investigate the potential host and parasite characteristics causing relapsing/persistent infection.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofab323