Sequence analysis of zebrafish chondromodulin-1 and expression profile in the notochord and chondrogenic regions during cartilage morphogenesis

• Published in: Mechanisms of development Vol. 105; no. 1; pp. 157 - 162
• Main Authors: Sachdev, Sherri Weiss, Dietz, Uwe H, Oshima, Yusuke, Lang, Michael R, Knapik, Ela W, Hiraki, Yuji, Shukunami, Chisa
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.07.2001
• Subjects: Amino Acid Sequence; Angiogenesis inhibitor; Animals; Cartilage; Cartilage - embryology; Cattle; Chondrogenesis; chondromodulin-1 ( chm1); Craniofacial; DNA, Complementary - metabolism; Ethmoid plate; Genetic locus; Growth Substances - biosynthesis; Growth Substances - genetics; Humans; In Situ Hybridization; Intercellular Signaling Peptides and Proteins; Maternal transcript; Membrane Proteins; Molecular Sequence Data; Notochord; Notochord - metabolism; Otic vesicle; Pectoral fin; Pharyngeal arch; Phylogeny; Radiation Hybrid Mapping; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Time Factors; Tissue Distribution; Trabecula; typeIIcollagen ( col2a1); Zebrafish; Zygote - metabolism; Ethmoid plate; Trabecula; Pharyngeal arch; Genetic locus; Pectoral fin; Zebrafish; Maternal transcript; Angiogenesis inhibitor; chondromodulin-1 ( chm1); Cartilage; Craniofacial; type II collagen ( col2a1); Otic vesicle; Chondrogenesis; Notochord

Chondromodulin-I (ChM-I) is suggested in higher vertebrate systems to function as a key regulatory protein for cartilage development. To further understand the process of chondrogenesis and the function of ChM-I, we have cloned the zebrafish cDNA for chondromodulin-1 ( chm1) and have mapped the chm1...