Sequence analysis of zebrafish chondromodulin-1 and expression profile in the notochord and chondrogenic regions during cartilage morphogenesis
Chondromodulin-I (ChM-I) is suggested in higher vertebrate systems to function as a key regulatory protein for cartilage development. To further understand the process of chondrogenesis and the function of ChM-I, we have cloned the zebrafish cDNA for chondromodulin-1 ( chm1) and have mapped the chm1...
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Published in | Mechanisms of development Vol. 105; no. 1; pp. 157 - 162 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Ireland
Elsevier Ireland Ltd
01.07.2001
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Subjects | |
Online Access | Get full text |
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Summary: | Chondromodulin-I (ChM-I) is suggested in higher vertebrate systems to function as a key regulatory protein for cartilage development. To further understand the process of chondrogenesis and the function of ChM-I, we have cloned the zebrafish cDNA for
chondromodulin-1 (
chm1) and have mapped the
chm1 gene locus. The expression profile of
chm1 was determined during zebrafish embryonic development and compared to that of
type
II
collagen (
col2a1). Maternal
chm1 transcripts were detected before midblastula transition and zygotic expression of
chm1 was first observed in the notochord at the 10-somite stage. At later developmental stages, c
hm1 expression was detected in areas surrounding the otic vesicles, in the developing craniofacial cartilage elements, and in the chondrogenic region of the pectoral fins. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0925-4773 1872-6356 |
DOI: | 10.1016/S0925-4773(01)00417-8 |