Sequence analysis of zebrafish chondromodulin-1 and expression profile in the notochord and chondrogenic regions during cartilage morphogenesis
Chondromodulin-I (ChM-I) is suggested in higher vertebrate systems to function as a key regulatory protein for cartilage development. To further understand the process of chondrogenesis and the function of ChM-I, we have cloned the zebrafish cDNA for chondromodulin-1 ( chm1) and have mapped the chm1...
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Published in | Mechanisms of development Vol. 105; no. 1; pp. 157 - 162 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Ireland Ltd
01.07.2001
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Abstract | Chondromodulin-I (ChM-I) is suggested in higher vertebrate systems to function as a key regulatory protein for cartilage development. To further understand the process of chondrogenesis and the function of ChM-I, we have cloned the zebrafish cDNA for
chondromodulin-1 (
chm1) and have mapped the
chm1 gene locus. The expression profile of
chm1 was determined during zebrafish embryonic development and compared to that of
type
II
collagen (
col2a1). Maternal
chm1 transcripts were detected before midblastula transition and zygotic expression of
chm1 was first observed in the notochord at the 10-somite stage. At later developmental stages, c
hm1 expression was detected in areas surrounding the otic vesicles, in the developing craniofacial cartilage elements, and in the chondrogenic region of the pectoral fins. |
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AbstractList | Chondromodulin-I (ChM-I) is suggested in higher vertebrate systems to function as a key regulatory protein for cartilage development. To further understand the process of chondrogenesis and the function of ChM-I, we have cloned the zebrafish cDNA for chondromodulin-1 (chm1) and have mapped the chm1 gene locus. The expression profile of chm1 was determined during zebrafish embryonic development and compared to that of type II collagen (col2a1). Maternal chm1 transcripts were detected before midblastula transition and zygotic expression of chm1 was first observed in the notochord at the 10-somite stage. At later developmental stages, chm1 expression was detected in areas surrounding the otic vesicles, in the developing craniofacial cartilage elements, and in the chondrogenic region of the pectoral fins. Chondromodulin-I (ChM-I) is suggested in higher vertebrate systems to function as a key regulatory protein for cartilage development. To further understand the process of chondrogenesis and the function of ChM-I, we have cloned the zebrafish cDNA for chondromodulin-1 ( chm1) and have mapped the chm1 gene locus. The expression profile of chm1 was determined during zebrafish embryonic development and compared to that of type II collagen ( col2a1). Maternal chm1 transcripts were detected before midblastula transition and zygotic expression of chm1 was first observed in the notochord at the 10-somite stage. At later developmental stages, c hm1 expression was detected in areas surrounding the otic vesicles, in the developing craniofacial cartilage elements, and in the chondrogenic region of the pectoral fins. |
Author | Shukunami, Chisa Sachdev, Sherri Weiss Knapik, Ela W Hiraki, Yuji Dietz, Uwe H Oshima, Yusuke Lang, Michael R |
Author_xml | – sequence: 1 givenname: Sherri Weiss surname: Sachdev fullname: Sachdev, Sherri Weiss organization: GSF-National Research Center for Environment and Health, Institute of Mammalian Genetics, D-85764 Neuherberg, Germany – sequence: 2 givenname: Uwe H surname: Dietz fullname: Dietz, Uwe H organization: GSF-National Research Center for Environment and Health, Institute of Mammalian Genetics, D-85764 Neuherberg, Germany – sequence: 3 givenname: Yusuke surname: Oshima fullname: Oshima, Yusuke organization: Department of Molecular Interaction and Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan – sequence: 4 givenname: Michael R surname: Lang fullname: Lang, Michael R organization: GSF-National Research Center for Environment and Health, Institute of Mammalian Genetics, D-85764 Neuherberg, Germany – sequence: 5 givenname: Ela W surname: Knapik fullname: Knapik, Ela W email: shukunam@frontier.kyoto-u.ac.jp organization: GSF-National Research Center for Environment and Health, Institute of Mammalian Genetics, D-85764 Neuherberg, Germany – sequence: 6 givenname: Yuji surname: Hiraki fullname: Hiraki, Yuji organization: Department of Molecular Interaction and Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan – sequence: 7 givenname: Chisa surname: Shukunami fullname: Shukunami, Chisa email: knapik@gsf.de organization: Department of Molecular Interaction and Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan |
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Keywords | Ethmoid plate Trabecula Pharyngeal arch Genetic locus Pectoral fin Zebrafish Maternal transcript Angiogenesis inhibitor chondromodulin-1 ( chm1) Cartilage Craniofacial type II collagen ( col2a1) Otic vesicle Chondrogenesis Notochord |
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USA doi: 10.1073/pnas.96.17.9745 contributor: fullname: Hukriede – volume: 43 start-page: 39 year: 1999 ident: 10.1016/S0925-4773(01)00417-8_BIB11 article-title: Spatiotemporal pattern of the mouse chondromodulin-I gene expression and its regulatory role in vascular invasion into cartilage during endochondral bone formation publication-title: Int. J. Dev. Biol. contributor: fullname: Shukunami |
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Snippet | Chondromodulin-I (ChM-I) is suggested in higher vertebrate systems to function as a key regulatory protein for cartilage development. To further understand the... |
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SubjectTerms | Amino Acid Sequence Angiogenesis inhibitor Animals Cartilage Cartilage - embryology Cattle Chondrogenesis chondromodulin-1 ( chm1) Craniofacial DNA, Complementary - metabolism Ethmoid plate Genetic locus Growth Substances - biosynthesis Growth Substances - genetics Humans In Situ Hybridization Intercellular Signaling Peptides and Proteins Maternal transcript Membrane Proteins Molecular Sequence Data Notochord Notochord - metabolism Otic vesicle Pectoral fin Pharyngeal arch Phylogeny Radiation Hybrid Mapping Reverse Transcriptase Polymerase Chain Reaction Sequence Analysis, DNA Sequence Homology, Amino Acid Time Factors Tissue Distribution Trabecula typeIIcollagen ( col2a1) Zebrafish Zygote - metabolism |
Title | Sequence analysis of zebrafish chondromodulin-1 and expression profile in the notochord and chondrogenic regions during cartilage morphogenesis |
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