Safety and Efficacy of Transjugular Intrahepatic Portosystemic Shunt Creation for the Treatment of Hepatic Hydrothorax

• Published in: Journal of vascular and interventional radiology Vol. 13; no. 4; pp. 385 - 390
• Main Authors: Spencer, E. Brooke, Cohen, Daniel T., Darcy, Michael D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2002
• Subjects: Adult; Aged; Female; Humans; Hydrothorax; Hydrothorax - etiology; Hydrothorax - mortality; Hydrothorax - therapy; Hypertension, Portal - complications; Liver Diseases - complications; Liver Transplantation; Male; Middle Aged; Portasystemic Shunt, Transjugular Intrahepatic - adverse effects; Portasystemic Shunt, Transjugular Intrahepatic - mortality; Severity of Illness Index; Shunts, portosystemic; Survival Analysis; Treatment Outcome; HHyd; Hydrothorax; PSG; Shunts, portosystemic; TIPS
• ISSN: 1051-0443; 1535-7732
• DOI: 10.1016/S1051-0443(07)61741-2

To evaluate safety and efficacy of transjugular intrahepatic portosystemic shunt (TIPS) creation for hepatic hydrothorax (HHyd). Twenty-one patients underwent TIPS creation for HHyd. A prospective TIPS database and medical records were reviewed. Clinical and radiographic outcomes were recorded as complete (symptom/effusion resolution), partial (improved symptoms/effusion), or none. Data patterns were examined with χ 2 tests and Kaplan-Meier analysis. Patients included 12 women and nine men, with a mean age of 56 years, all with Child class B ( n = 7) or C( n = 14) disease. The technical success rate was 100%. Mean follow-up was 223 days. Twenty-nine percent (six of 21) died within 30 days of TIPS creation, 10% (two of 21) underwent transplantation within 30 days, and 62% (13 of 21) survived beyond 30 days. Data were incomplete in two patients. Clinical response was classified as complete in 63% (12 of 19), partial in 11% (two of 19), and none in 26% (five of 19). Radiographic response was classified as complete in 30% (six of 20), partial in 50% (10 of 20), and none in 20% (four of 20). Nonresponders had multisystem organ failure, and all but one died within 30 days. However, of the 13 patients surviving longer than 30 days, 10 (77%) had a complete clinical response. TIPS is a relatively safe and effective method of controlling HHyd. The majority of patients experienced improvement or resolution of clinical symptoms with a variable reduction in the quantity of pleural fluid. There was a tendency among nonresponders to die within 30 days.