A review on phytochemicals as combating weapon for multidrug resistance in cancer

• Published in: Journal of asian natural products research Vol. 27; no. 2; pp. 107 - 125
• Main Authors: Gupta, Sharwan, Mehra, Anuradha, Sangwan, Rekha
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.02.2025; Taylor & Francis Ltd
• Subjects: Alkaloids; Anticancer; Antineoplastic Agents, Phytogenic - pharmacology; Antineoplastic drugs; Cancer; Chemotherapy; Drug metabolism; Drug resistance; Drug Resistance, Multiple - drug effects; Drug Resistance, Neoplasm - drug effects; drug therapy; drugs; Efflux; Flavonoids; Humans; MDR; mechanism of action; Molecular Structure; Multidrug resistance; multiple drug resistance; Natural products; Neoplasms - drug therapy; pharmacokinetics; Phytochemicals; Phytochemicals - chemistry; Phytochemicals - pharmacology; Therapeutic targets; transporters; Alkaloids; Flavonoids; MDR; Anticancer; Natural products
• ISSN: 1028-6020; 1477-2213; 1477-2213
• DOI: 10.1080/10286020.2024.2386678

One can recognize multidrug resistance (MDR) and residue as a biggest difficulty in cancer specialist. Chemotherapy-resistant cancer may be successfully treated by combining MDR-reversing phytochemicals with anticancer drugs. Though, clinical application of phytochemicals either alone or in conjunction with chemotherapy is still in its early stages or requires more research to determine their safety and efficacy. In this review we highlighted topics related to MDR in cancer, including an introduction to subject, mechanism of action of efflux pump, specific proteins involved in drug resistance, altered drug targets, increased drug metabolism, and potential role of phytochemicals in overcoming drug resistance.