Structure of a human common cold virus and functional relationship to other picornaviruses

We report the first atomic resolution structure of an animal virus, human rhinovirus 14. It is strikingly similar to known icosahedral plant RNA viruses. Four neutralizing immunogenic regions have been identified. These, and corresponding antigenic sequences of polio and foot-and-mouth disease virus...

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Bibliographic Details
Published inNature (London) Vol. 317; no. 6033; p. 145
Main Authors Rossmann, M G, Arnold, E, Erickson, J W, Frankenberger, E A, Griffith, J P, Hecht, H J, Johnson, J E, Kamer, G, Luo, M, Mosser, A G
Format Journal Article
LanguageEnglish
Published England 01.09.1985
Subjects
Amino Acids - analysis
Antigens, Viral - analysis
Biological Evolution
Capsid - analysis
Chemical Phenomena
Chemistry
Crystallography
Models, Molecular
Picornaviridae - ultrastructure
Receptors, Virus - analysis
Rhinovirus - ultrastructure
Serotyping
Viral Proteins - analysis
Viral Structural Proteins
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Summary:We report the first atomic resolution structure of an animal virus, human rhinovirus 14. It is strikingly similar to known icosahedral plant RNA viruses. Four neutralizing immunogenic regions have been identified. These, and corresponding antigenic sequences of polio and foot-and-mouth disease viruses, reside on external protrusions. A large cleft on each icosahedral face is probably the host cell receptor binding site.
ISSN:0028-0836
DOI:10.1038/317145a0